溃疡性结肠炎复发因素的研究现状  

Recurrent factors of ulcerative colitis

作　　者：李秀美 徐宁 Li Xiumei;Xu Ning(First Wavd,Department of Gastroenterology,Yantai Affiliated Hospital of Binzhou Medical University,Yantai 264100,China)

机构地区：[1]滨州医学院烟台附属医院消化内科一病区,山东264100

出　　处：《国际医药卫生导报》2021年第21期3429-3432,共4页International Medicine and Health Guidance News

摘　　要：溃疡性结肠炎(ulcerative colitis,UC)是炎症性肠病(inflammatory bowel disease,IBD)的常见类型之一,是一种慢性免疫介导性的肠道疾病,病变以直肠或远端结肠的浅溃疡为主,严重者可累及全结肠。UC在我国发病率逐渐升高,其病因复杂、病程漫长、病变范围及轻重程度各异,故在临床上常呈现复发率较高的特点。现如今关于UC复发的研究热点主要在肠外表现、肠道感染(菌群失调)、饮食等因素上,但没有那么严格的临床对照实验研究来定义这些相关诱因可能的机制及影响,因此需要大量细致的研究来加以证实。现针对常见复发危险因素进行综述,希望对改善患者预后及减少复发提供帮助,也为今后研究影响溃疡性结肠炎复发的因素提供方向。Ulcerative colitis(UC)is one of the most common types of inflammatory bowel disease(IBD).It is a chronic immune-mediated bowel disease that is characterized by shallow ulcers of rectum or distal colon,or of the entire colon in severe cases.The incidence of UC in China is gradually increasing.Its etiology is complex,its disease course is long,and the range and severity of the lesions are different,so it often presents a high recurrence rate in clinical practice.At present,the research hot spots on UC relapse mainly focuses on extra-intestinal manifestations,intestinal infection(flora disorder),diet,and other factors.However,there are no strict clinical controlled experimental studies defining the possible mechanism and influence of these related causes,so it is to be confirmed by a large number of detailed studies.This paper reviews the common risk factors for its recurrence,hoping to improve the patients'prognosis and reduce recurrence,and to provide a direction for future research on the factors affecting the recurrence of UC.

关 键 词：溃疡性结肠炎 复发 影响因素 综述 

分 类 号：R574.62[医药卫生—消化系统]