针灸联合氢溴酸西酞普兰片对卒中后抑郁患者的抑郁状态及睡眠影响的90例临床研究  

Clinical study on the efficacy of acupuncture and citalopram hydrobromide on the depressive state and sleep of 90 patients with post-stroke depression

作　　者：李传游[1] 李业余 马辉[1] 魏春玲[1] 盛蕾[1] 顾兆军[1] Li Chuanyou

机构地区：[1]南京中医药大学第二附属医院暨江苏省第二中医院,江苏南京210017 [2]南京双闸社区卫生服务中心,江苏南京210019

出　　处：《中医临床研究》2021年第19期53-56,共4页Clinical Journal Of Chinese Medicine

基　　金：全国名老中医学术经验传承项目;江苏省卫生健康委员会科研课题(Z2018005);江苏省第二中医院院内课题(SEZJJP2018026);江苏省第二中医院院内课题(SEZ2019004)。

摘　　要：目的:观察针灸联合氢溴酸西酞普兰片治疗卒中后抑郁(Post-Stroke Depression,PSD)的临床疗效及对睡眠结构的影响。方法:将90例缺血性PSD患者随机分为治疗组和对照组,每组45例。对照组给予口服氢溴酸西酞普兰片,治疗组在对照组基础上给予针刺治疗。分别于治疗前及2、4、8周后进行汉密尔顿抑郁量表-17(Hamilton Depression Scale,HAMD-17)评分,观察治疗8周前后多导睡眠图相关指标变化,并评估临床疗效。结果:治疗2、4、8周后,两组的HAMD-17评分均较治疗前有显著改善(P<0.01),且治疗组优于对照组(P<0.01);治疗8周后两组睡眠总时间延长、睡眠潜伏期缩短、觉醒次数减少、睡眠效率及睡眠维持率提高、快速动眼睡眠和非快速动眼睡眠(III+IV期)延长(P<0.05),非快速动眼睡眠I和非快速动眼睡眠II期无显著变化(P>0.05),且治疗组优于对照组(P<0.05)。结论:针灸联合氢溴酸西酞普兰片可改善缺血性PSD患者的抑郁症状,同时可以诱导睡眠,改善睡眠节律和睡眠结构,提高睡眠质量。Objective:To observe the clinical efficacy of acupuncture and moxibustion plus citalopram hydrobromide on post-stroke depression and sleep structure.Methods:90 patients with post-ischemic stroke depression were randomly divided into the treatment group and the control group,with 45 cases in each group.The control group was given oral citalopram hydrobromide,the treatment group was given acupuncture more.Results:After 2,4,and 8 weeks of treatment,the HAMD-17 scores in two groups were significantly improved compared to before treatment(P<0.01),and those in the treatment group were better than the control group(P<0.01).After 8 weeks of treatment,the total sleep time in the two groups was prolonged,the sleep latency was shortened,the number of awakenings was reduced,the sleep efficiency and sleep maintenance rate were improved,the rapid eye movement sleep and non-rapid eye movement sleep(phase III+IV)were prolonged(P<0.05),there was no significant change in non-rapid eye movement sleep I and II stage(P>0.05),and those in the treatment group was better than the control group(P<0.05).Conclusion:Acupuncture plus citalopram hydrobromide can improve the depressive symptoms of patients with post-ischemic stroke depression,at the same time can induce sleep,improve sleep rhythm and sleep structure,and improve sleep quality.

关 键 词：针灸 卒中后抑郁 睡眠障碍 多导睡眠图 

分 类 号：R749.4[医药卫生—神经病学与精神病学]