下呼吸道菌群失调与肺癌发生发展关系的研究进展  

Research progress in lower respiratory tract flora dysbiosis associated with the development of lung cancer

作　　者：陈倩倩 张景熙[1] 白冲[1] Chen Qianqian;Zhang Jingxi;Bai Chong(Department of Respiratory Medicine,Changhai Hospital Affiliated to Naval Military Medical University,Shanghai 200433,China)

机构地区：[1]上海市第二军医大学附属长海医院呼吸科,200433

出　　处：《国际呼吸杂志》2021年第20期1579-1583,共5页International Journal of Respiration

基　　金：国家自然科学基金(81670016)。

摘　　要：菌群失调与肿瘤发生发展密切相关,如肠道菌群与结肠癌,口腔菌群与口腔肿瘤。肺癌是目前最为常见的恶性肿瘤之一,近来研究发现下呼吸道菌群可能通过改变肺部炎症、免疫、代谢微环境等影响肺癌的发生发展及治疗效果。本综述就下呼吸道菌群失调与肺癌发生发展相关的近年研究进行分析,以期为今后探索肺癌诊治新策略提供新的方向。Disruption of the symbiotic balance of the human microbiome is closely related to neoplasms such as intestinal flora and colon cancer,oral flora and oral tumors.The incidence and mortality of lung cancer are the highest among all malignancies.Emerging evidence has suggested that the lower respiratory tract flora may be closely related to lung cancer at multiple levels by affecting inflammation,immune or metabolic microenvironment.This review summarized current research findings describing relevance of lower respiratory tract flora and lung cancer.A better knowledge of the interplay between the lower respiratory tract flora and lung cancer may promote the development of innovative strategies for diagnosis and treatment in lung cancer.

关 键 词：肺肿瘤 呼吸道感染 细菌感染和真菌病 肿瘤微环境 

分 类 号：R734.2[医药卫生—肿瘤]