β-淀粉样蛋白的两种结局:淀粉样脑血管病及阿尔茨海默病  

Progress in the study of the correlation between cerebral amyloid angiopathy and Alzheimer’s disease

作　　者：陆正齐[1] 李钰 LU Zheng-qi;LI Yu(Department of Neurology,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,Guangdong,China)

机构地区：[1]中山大学附属第三医院神经内科,广州510630

出　　处：《中国现代神经疾病杂志》2021年第10期823-827,共5页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：广东省广州市重点领域研发计划项目(项目编号:202007030010)。

摘　　要：年龄相关认知功能障碍主要与神经退行性变和脑血管病有关。衰老引起的认知功能障碍如淀粉样脑血管病和阿尔茨海默病的病理改变均为β-淀粉样蛋白(Aβ)沉积,但其导致脑损伤的作用机制存有差异。本文阐述Aβ沉积这一共同作用机制导致淀粉样脑血管病和阿尔茨海默病的致病途径、两种疾病病理学机制的相互影响以及如何共同导致认知功能障碍和神经功能障碍。Age-related cognitive dysfunction is mainly related to neurodegenerative and cerebrovascular disease.The major pathological changes of cognitive dysfunction caused by aging such as cerebral amyloid angiopathy(CAA) and Alzheimer’ s disease(AD) are β-amyloid protein(Aβ) deposition,however,there are differences in the mechanism of its effect on brain damage.This article described how the common mechanism of Aβ deposition leads to the pathogenesis of CAA and AD,the mutual influence of the pathological mechanisms of the two diseases,and how Aβ deposition simultaneously cause cognitive dysfunction and neurological dysfunction.

关 键 词：脑淀粉样血管病 阿尔茨海默病 淀粉样β肽类 综述 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]