中枢神经系统脱髓鞘疾病PET示踪剂研究进展  

Research progress of PET tracer for monitoring demyelinating diseases of central nervous system

作　　者：高一宁 张敏[2] 周勤明 刘军[1] 陈晟[1] GAO Yi-ning;ZHANG Min;ZHOU Qin-ming;LIU Jun;CHEN Sheng(Department of Neurology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;Department of Nuclear Medicine,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院神经科,200025 [2]上海交通大学医学院附属瑞金医院核医学科,200025

出　　处：《中国现代神经疾病杂志》2021年第10期899-904,共6页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：国家自然科学基金资助项目(项目编号:81671241)。

摘　　要：目前临床缺乏监测中枢神经系统脱髓鞘疾病髓鞘脱失和再生的影像学手段。现有的各种MRI技术均以间接方式检测髓鞘脱失情况,易受其他干扰因素的影响。PET作为一种可在分子水平对神经系统疾病进行成像的技术,可以实现功能、代谢、生化的实时成像,弥补MRI的局限性。近年来,髓鞘PET显像示踪剂发展迅速,目前以髓鞘为靶点的示踪剂主要包括刚果红衍生物、二苯乙烯衍生物、硫磺素衍生物。新型多模态医学影像学技术PET/MRI结合PET分子水平成像和MRI软组织分辨率高的优势,实现解剖结构、功能、代谢、生化影像的实时融合,未来可能成为监测中枢神经系统脱髓鞘疾病的有效手段。At present,there is a Tack of imaging methods to monitor demyelination and myelin regeneration of central nervous system demyelinating diseases.All kinds of MRI techniques are used to measure demyelination indirectly and are vulnerable to other interference factors.PET is an imaging technique that can image central nervous system diseases at the molecular level.It can realize real-time imaging of function,metabolism,biochemistry and make up for the limitations of MRI.PET myelin imaging tracers have developed rapidly in recent years.There are currently three types of PET tracers targeting myelin:congo red derivatives,diphenylethylene derivatives and sulforaphane derivatives.The new multimodal medical imaging technology PET/MRI combines the advantages of PET molecular level imaging and MRI high soft tissue resolution to realize real-time fusion of anatomical structure and functional,metabolic,biochemical images.In the future,it may become an effective means to monitor demyelinating lesions of the central nervous system.

关 键 词：脱髓鞘自身免疫疾病 中枢神经系统 正电子发射断层显像术 磁共振成像 放射性示踪剂 综述 

分 类 号：R744.5[医药卫生—神经病学与精神病学]