Major depressive disorder:Validated treatments and future challenges  

作　　者：Rabie Karrouri Zakaria Hammani Roukaya Benjelloun Yassine Otheman 

机构地区：[1]Department of Psychiatry,Moulay Ismaïl Military Hospital,Faculty of Medicine and Pharmacy,Sidi Mohamed Ben Abdellah University,Fez 30070,Morocco [2]Department of Psychiatry,Faculty of Medicine,Mohammed VI University of Health Sciences,Casablanca 20000,Morocco

出　　处：《World Journal of Clinical Cases》2021年第31期9350-9367,共18页世界临床病例杂志

摘　　要：Depression is a prevalent psychiatric disorder that often leads to poor quality of life and impaired functioning.Treatment during the acute phase of a major depressive episode aims to help the patient reach a remission state and eventually return to their baseline level of functioning.Pharmacotherapy,especially selective serotonin reuptake inhibitors antidepressants,remains the most frequent option for treating depression during the acute phase,while other promising pharmacological options are still competing for the attention of practitioners.Depressionfocused psychotherapy is the second most common option for helping patients overcome the acute phase,maintain remission,and prevent relapses.Electroconvulsive therapy is the most effective somatic therapy for depression in some specific situations;meanwhile,other methods have limits,and their specific indications are still being studied.Combining medications,psychotherapy,and somatic therapies remains the most effective way to manage resistant forms of depression.

关 键 词：DEPRESSION Treatment Antidepressants PSYCHOTHERAPY Cognitive-behavioral therapy Somatic therapies Electroconvulsive therapy 

分 类 号：R749.4[医药卫生—神经病学与精神病学]