Validation of diagnostic strategies of autoimmune atrophic gastritis:A case report  

作　　者：Wen-Jing Sun Qiang Ma Ren-Zheng Liang Ya-Mei Ran Li Zhang Juan Xiao Yong-Mei Peng Bin Zhan 

机构地区：[1]Department of Gastroenterology,Hepatology and Endocrinology,Thirteenth Peoples’Hospital of Chongqing,Chongqing 400053,China [2]Department of Pathology,Daping Hospital,Army Medical University,Chongqing 400042,China

出　　处：《World Journal of Clinical Cases》2021年第31期9557-9563,共7页世界临床病例杂志

摘　　要：BACKGROUND Autoimmune atrophic gastritis(AAG)is a type of chronic gastritis that mainly affects the gastric corpus.Due to the lack of standard diagnostic criteria and overlaps with the courses of Helicobacter pylori-related atrophic gastritis,reports on the diagnostic strategy of AAG at an early stage are limited.CASE SUMMARY A 71-year-old woman with severe anemia was diagnosed with AAG.Endoscopic views and pathological findings showed the coexistence of normal mucosa in the gastric antrum and atrophic mucosa in the gastric fundus.Serological tests showed that anti-parietal cell antibodies and anti-intrinsic factor antibodies were both positive.Immunohistochemical results,which showed negative H^(+)-K^(+)ATPase antibody staining and positive chromogranin A(CgA)staining,confirmed the mechanism of this disease.After vitamin B12 and folic acid supplementation,the patient recovered well.CONCLUSION Successful diagnosis of AAG includes serological tests,endoscopic characteristics,and immunohistochemistry for H^(+)-K^(+)ATPase and CgA antibodies.

关 键 词：Autoimmune atrophic gastritis Endoscopy H^(+)-K^(+)ATPase Chromogranin A Immunohistochemical examination Case report©The Author(s)2021.Published by Baishideng Publishing Group Inc.All rights reserved. 

分 类 号：R573.3[医药卫生—消化系统]