T-cell lymphoblastic lymphoma with extensive thrombi and cardiac thrombosis:A case report and review of literature  

作　　者：Ying-Ying Ma Quan-Chao Zhang Xu Tan Xi Zhang Cheng Zhang 

机构地区：[1]Department of Hematology,State Key Laboratory of Trauma,Burns and Combined Injury,Xinqiao Hospital of Army Medical University,Chongqing 400037,China [2]Department of Nephrology,The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing,Chongqing Clinical Research Center of Kidney and Urology Diseases,Xinqiao Hospital,Army Medical University(Third Military Medical University),Chongqing 400037,China

出　　处：《World Journal of Clinical Cases》2021年第31期9607-9616,共10页世界临床病例杂志

摘　　要：BACKGROUND T-lymphoblastic lymphoma(T-LBL),a neoplasm of immature T-cell precursors or lymphoblasts,is a clinically aggressive disease.In general,patients with T-LBL have a poor prognosis and often have high-risk clinical features,such as mediastinal masses,central nervous system infiltration,or other indications of high tumor burden;however,extensive thrombi are not common.CASE SUMMARY A 27-year-old woman presented to the Department of General Surgery with cervical lymph node enlargement accompanied by cough,wheezing,and palpitation for 3 mo.A complete blood count showed a white blood cell count of 1.6×10^(9)/L,a hemoglobin concentration of 135 g/L,and a platelet count of 175×10^(9)/L.A biopsy sample of the lymph node mass indicated T-cell lymphoblastic lymphoma,and the bone marrow immunophenotype indicated early T-cell precursor acute lymphoblastic leukemia(ETP-ALL).Abdominal and chest enhanced computed tomography showed thrombi in the superior vena cava,inferior vena cava,right hepatic vein,azygos vein,and right atrium.The ultrasonic cardiogram showed a thrombus in the right atrium of 5.23 cm×4.21 cm.The patient was first treated with low-dose dexamethasone and lowmolecular-weight heparin followed by 2 cycles of chemotherapy.Then,the ultrasonic cardiogram showed that thrombus in the right atrium had disappeared and the patient had achieved complete cytological remission.The maintenance therapy of the patient included chidamide 30 mg/wk,and she survived for 6 mo.CONCLUSION The incidence of venous thromboembolism is high in lymphoma;however,extensive thrombi with heart thrombosis is rare.Chemotherapy is the major method of treatment for lymphoma with thrombosis.We successfully treated a patient with T-LBL complicated by extensive thrombi,including a large right atrial thrombus,with combined chemotherapy containing liposomal doxorubicin,and the patient achieved complete remission.Maintenance therapy with chidamide was also effective.

关 键 词：T-lymphoblastic lymphoma THROMBUS Cardiac thrombosis Chemotherapy Case report 

分 类 号：R733.1[医药卫生—肿瘤]