Dynamic changes in the radiologic manifestation of a recurrent checkpoint inhibitor related pneumonitis in a non-small cell lung cancer patient:A case report  

作　　者：Pei-Xin Tan Wei Huang Ping-Ping Liu Yi Pan Yan-Hai Cui 

机构地区：[1]Department of Radiation Oncology,Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences,Guangzhou 510080,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2021年第30期9108-9113,共6页世界临床病例杂志

摘　　要：BACKGROUND As immune checkpoint inhibitors(ICIs)have become widely used in lung cancer treatment,immune-related adverse events(irAEs)warrant sufficient attention.Checkpoint inhibitor-related pneumonitis(CIP)is one of the most concerning adverse events as it is uncommon but life threatening.CASE SUMMARY The patient whose case is reported here experienced three episodes of CIP in a span of 4 mon.Interestingly,the three episodes of CIP involved different regions of the lung separately.Taking these pneumonitis areas together makes nearly a whole lung area.CONCLUSION This case showed that recurrent CIPs may occur repeatedly until the whole lung is involved,suggesting that the follow-up period of CIP should be long enough,and the rechallenge of ICI should be done with due caution.

关 键 词：Checkpoint inhibitor-related pneumonitis Lung cancer Radiology Immune checkpoint inhibitors Recurrent pneumonitis Case report 

分 类 号：R734.2[医药卫生—肿瘤]