非甾体类抗炎药相关小肠损伤的研究进展  

Research progress of non-steroidal anti-inflammatory drug-induced small intestinal injury

作　　者：罗洋 朱兰平 雷月 赵经文 王邦茂[1] 陈鑫[1] Yang Luo;Lan-Ping Zhu;Yue Lei;Jing-Wen Zhao;Bang-Mao Wang;Xin Chen(Department of Gastroenterology and Hepatology,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院消化内科,天津市300052

出　　处：《世界华人消化杂志》2021年第20期1191-1200,共10页World Chinese Journal of Digestology

基　　金：天津市科技计划项目,No.19PTZWHZ00090;天津市自然科学基金,No.18JCZDJC45200;天津市研究生科研创新项目,No.2019YJSB108。

摘　　要：非甾体类抗炎药(non-steroidal anti-inflammatory drugs,NSAIDs)是一种抗炎镇痛及抗血小板药物,在全世界被广泛使用.但随着NSAIDs的长期应用,其并发症逐渐受到人们的关注.以往在临床上关注较多的是其导致的上消化道并发症,但随着内窥镜如胶囊内镜和双气囊小肠镜等的普及,人们发现NSAIDs引起的小肠损伤也并不少见.虽然大部分患者并无明显症状,但仍有部分患者出现了明显的症状或复杂的溃疡,需要进行治疗干预.然而,针对NSAIDs相关性肠病的药物尚未被研发,因此,进一步研究NSAIDs相关肠病的发病机制并制定合适的防治策略是有必要的.本文对NSAIDs所致小肠损伤的流行病学、临床表现、诊断、危险因素、发病机制和治疗进行了归纳总结,为NSAIDs的使用及其并发症的防治提供参考.Non-steroidal anti-inflammatory drugs(NSAIDs)are used widely around the world because of their anti-inflammatory,analgesic,and antiplatelet activity.However,long-term application of NSAIDs can lead to complications.Previously,the clinical attention was dedicated to the NSAID-induced upper gastrointestinal complications.Recently,the detection rate of small intestinal damage related to NSAIDs has increased due to the wide use of endoscopes such as capsule endoscopy and double-balloon colonoscopy.Although the majority of patients have no significant symptoms,there are still a small percentage of patients who develop obvious symptoms or complicated ulcers that require therapeutic intervention.Despite significant advances in our understanding of NSAIDs,the treatment modality and regimen for NSAID-induced small intestinal damage have remained relatively unclear.This article will provide a comprehensive overview of NSAID-induced small intestinal damage with regard to the epidemiology,clinical manifestations,diagnosis,risk factors,pathogenesis,and treatment,in order to provide informative evidence for clinical practice.

关 键 词：非甾体抗炎药 小肠损伤 干预治疗 

分 类 号：R574.5[医药卫生—消化系统]