肝窦内皮细胞与非酒精性脂肪性肝病的研究进展  

Research progress of sinusoidal endothelial cells in nonalcoholic fatty liver disease

作　　者：曹婕露 严峻彬 吴锦婷 陈芝芸[1] Jie-Lu Cao;Jun-Bin Yan;Jin-Ting Wu;Zhi-Yun Chen(The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou Command,Hangzhou 310006,Zhejiang Province,China)

机构地区：[1]浙江中医药大学附属第一医院,浙江省杭州市310006

出　　处：《世界华人消化杂志》2021年第21期1254-1260,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金,No.81573761和No.81976310.

摘　　要：非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是一个与代谢综合征相关的日益扩大的健康问题.肝窦内皮细胞(liver sinusoidal endothelial cells,LSECs)是位于血液与其他肝细胞类型之间高度专业化的内皮细胞,由窗孔组成,具有高内吞能力,并在维持肝脏整体稳态中发挥重要作用.病理条件下LSECs可能是多种慢性肝病的关键事件.本篇综述介绍了LSECs的独特生理结构和功能,重点总结了NAFLD中LSECs的主要变化(包括肝窦毛细血管化、血管生成、血管收缩、促炎和促纤维化)及其发生机制,还涉及LSECs对NAFLD进展的影响,旨在说明LSECs靶向治疗对NAFLD具有潜在疗效.Nonalcoholic fatty liver disease(NAFLD)is a growing health problem associated with metabolic syndrome.Liver sinusoidal endothelial cells(LSECs)are highly specialized endothelial cells located between the blood and other liver cell types.They are composed of window pores,have high endocytosis,and play an important role in maintaining the overall liver homeostasis.Under pathological conditions,LSECs may be the key event of a variety of chronic liver diseases.In this review,we introduce the unique physiological structure and function of LSECs,summarize the main changes of LSECs in NAFLD(including sinohepatic capillarization,angiogenesis,vasoconstriction,proinflammatory effect,and fibrosis)and their pathogenesis,and discuss the influence of LSECs on the progression of NAFLD,with an aim to demonstrate the potential efficacy of LSECS targeted therapy for NAFLD.

关 键 词：肝窦内皮细胞 非酒精性脂肪性肝病 

分 类 号：R575.5[医药卫生—消化系统]