吉西他滨联合奥沙利铂方案在Ⅳ期原发性肝癌治疗中的临床应用  

Clinical application of gemcitabine combined with oxaliplatin in the treatment of stageⅣprimary liver cancer

作　　者：杨宇 朱丹 孙科 YANG Yu;ZHU Dan;SUN Ke(Third Ward of Radiotherapy,Fushun Fourth Hospital,Fushun 113123,China)

机构地区：[1]抚顺市第四医院放疗三病房,113123

出　　处：《中国现代药物应用》2021年第20期121-123,共3页Chinese Journal of Modern Drug Application

摘　　要：目的观察吉西他滨联合奥沙利铂方案在Ⅳ期原发性肝癌治疗中的临床应用效果。方法48例Ⅳ期原发性肝癌患者,按照治疗方法不同分为实验组与对照组,各24例。实验组应用吉西他滨联合奥沙利铂方案治疗,对照组单纯应用吉西他滨治疗。比较两组治疗总有效率、不良反应发生情况。结果实验组治疗总有效率为66.67%,高于对照组的37.50%,差异有统计学意义(P<0.05)。两组患者中性粒细胞减少、血小板减少、胃肠道反应、脱发、肝功能损伤、肾功能损伤及皮疹等不良反应发生率比较,差异无统计学意义(P>0.05)。结论Ⅳ期原发性肝癌患者应用吉西他滨联合奥沙利铂方案的治疗效果显著优于单纯应用吉西他滨。Objective To observe the clinical effect of gemcitabine combined with oxaliplatin in the treatment of stageⅣprimary liver cancer.Methods A total of 48 patients with stageⅣprimary liver cancer were divided into experimental group and control group according to different treatment methods,with 24 cases in each group.The experimental group was treated with gemcitabine and oxaliplatin,and the control group was treated with gemcitabine alone.The total efficiency of treatment and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was 66.67%,which was higher than 37.50%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of neutropenia,thrombocytopenia,gastrointestinal reactions,alopecia,liver damage,renal damage,and skin rashes between the two groups(P>0.05).Conclusion The effect of gemcitabine combined with oxaliplatin is better than that of gemcitabine alone in the treatment of stageⅣprimary liver cancer.

关 键 词：吉西他滨 奥沙利铂 晚期 原发性肝癌 

分 类 号：R735.7[医药卫生—肿瘤]