Colorectal cancer patients in a tertiary hospital in Indonesia: Prevalence of the younger population and associated factors  

作　　者：Dadang Makmun Marcellus Simadibrata Murdani Abdullah Ari F Syam Hamzah Shatri Achmad Fauzi KakaRenaldi Hasan Maulahela Amanda P Utari Rabbinu R Pribadi Virly N Muzellina Saskia A Nursyirwan 

机构地区：[1]Division of Gastroenterology,Pancreatobiliary&Digestive Endoscopy,Department of Internal Medicine,Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital,Jakarta 10430,Indonesia [2]Clinical Epidemiology Unit,Department of Internal Medicine,Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital,Jakarta 10430,Indonesia

出　　处：《World Journal of Clinical Cases》2021年第32期9804-9814,共11页世界临床病例杂志

摘　　要：BACKGROUND An increasing trend in colorectal cancer(CRC)occurring at younger ages has been observed worldwide,even though incidence is declining in the general population.Most currently available guidelines still recommend CRC screening for older populations,despite an alarming rise in early-onset CRC incidence.Risk stratification is necessary to further determine the population most at risk for early-onset CRC.However,epidemiological data on related clinical characteristics and potential risk factors,especially in developing countries,have not been widely reported.AIM To investigate the prevalence,demographics,clinicopathologic features,and associated factors of young-onset CRC patients in a tertiary hospital in Indonesia.METHODS Patients undergoing colonoscopy examination between 2008 and 2019,yielding a diagnosis of CRC were identified from medical records.The subjects were classified into two groups according to their age at diagnosis,namely early-onset(18-49 years old)and late-onset(≥50-years-old).Demographic data,characteristics,and risk factors of both onset age groups were evaluated using the chisquare and Fisher’s exact test.RESULTS Among 495 CRC patients confirmed by histopathology,205(41.4%)were classified as early-onset and 290(58.6%)as late-onset.Most subjects in the earlyonset CRC group were male(53.7%),with 89.8%displaying adenocarcinoma histopathology.A majority(78%)of the early-onset CRC patients had left-sided tumors,with the rectum(41%)and rectosigmoid(17.6%)being the most common sites.Abdominal pain was the most frequent symptom in the early-onset CRC patients(55.6%),which was significantly higher than that in the late-onset CRC patients(43.8%,P<0.05).Early-onset CRC cases were more likely to be underweight(34.6%vs 20.0%,P<0.001)compared to late-onset CRC cases.The proportion of subjects with suspected hereditary nonpolyposis colorectal cancer(HNPCC)was also higher in the early-onset CRC group than in the late-onset age group(9.3%vs 4.1%,P<0.05).However,no difference was observed in the pa

关 键 词：Colorectal cancer Early onset EPIDEMIOLOGY Associated factors Tertiary hospital Indonesia 

分 类 号：R735.34[医药卫生—肿瘤]