Role of human nucleoside transporters in pancreatic cancer and chemoresistance  

作　　者：Carly Jade Carter Ahmed H Mekkawy David L Morris 

机构地区：[1]Hepatobiliary and Surgical Oncology Unit,Department of Surgery,St George Hospital,University of New South Wales,Sydney 2217,New South Wales,Australia [2]Mucpharm Pty Ltd,Australia

出　　处：《World Journal of Gastroenterology》2021年第40期6844-6860,共17页世界胃肠病学杂志（英文版）

摘　　要：The prognosis of pancreatic cancer is poor with the overall 5-year survival rate of less than 5%changing minimally over the past decades and future projections predicting it developing into the second leading cause of cancer related mortality within the next decade.Investigations into the mechanisms of pancreatic cancer development,progression and acquired chemoresistance have been constant for the past few decades,thus resulting in the identification of human nucleoside transporters and factors affecting cytotoxic uptake via said transporters.This review summaries the aberrant expression and role of human nucleoside transports in pancreatic cancer,more specifically human equilibrative nucleoside transporter 1/2(hENT1,hENT2),and human concentrative nucleoside transporter 1/3(hCNT1,hCNT3),while briefly discussing the connection and importance between these nucleoside transporters and mucins that have also been identified as being aberrantly expressed in pancreatic cancer.The review also discusses the incidence,current diagnostic techniques as well as the current therapeutic treatments for pancreatic cancer.Furthermore,we address the importance of chemoresistance in nucleoside analogue drugs,in particular,gemcitabine and we discuss prospective therapeutic treatments and strategies for overcoming acquired chemoresistance in pancreatic cancer by the enhancement of human nucleoside transporters as well as the potential targeting of mucins using a combination of mucolytic compounds with cytotoxic agents.

关 键 词：Pancreatic cancer GEMCITABINE Human nucleoside transporters Human equilibrative nucleoside transporters Human concentrative nucleotide transporters MUCINS 

分 类 号：R735.9[医药卫生—肿瘤]