Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities  

作　　者：Manish Manrai TVSVGK Tilak Saurabh Dawra Sharad Srivastava Anupam Singh 

机构地区：[1]Department of Internal Medicine,Armed Forces Medical College,Pune 411040,Maharashtra,India [2]Department of Internal Medicine,Command Hospital,Pune 411040,Maharashtra,India [3]Department of Gastroenterology,Post Graduate Institute of Medical Education and Research,Chandigarh 160011,India

出　　处：《World Journal of Gastroenterology》2021年第39期6572-6589,共18页世界胃肠病学杂志（英文版）

摘　　要：Pancreatic carcinoma(PC)is one of the leading causes of cancer-related deaths worldwide.Despite early detection and advances in therapeutics,the prognosis remains dismal.The outcome and therapeutic approach are dependent on the stage of PC at the time of diagnosis.The standard of care is surgery,followed by adjuvant chemotherapy.The advent of newer drugs has changed the landscape of adjuvant therapy.Moreover,recent trials have highlighted the role of neoadjuvant therapy and chemoradiotherapy for resectable and borderline resectable PC.As we progress towards a better understanding of tumor biology,genetics,and microenvironment,novel therapeutic strategies and targeted agents are now on the horizon.We have described the current and emerging therapeutic strategies in PC.

关 键 词：Resectable pancreatic carcinoma Borderline resectable pancreatic carcinoma Locally advanced pancreatic carcinoma Adjuvant therapy Neoadjuvant therapy Newer advances in pancreatic carcinoma 

分 类 号：R735.9[医药卫生—肿瘤]