Dendrimer-decorated nanogels:Efficient nanocarriers for biodistribution in vivo and chemotherapy of ovarian carcinoma  

作　　者：Xin Li Zhijun Ouyang Helin Li Chaolei Hu Pabitra Saha Lingxi Xing Xiangyang Shi Andrij Pich 

机构地区：[1]DWI-Leibniz-Institute for Interactive Materials e.V,52056,Aachen,Germany [2]Institute for Technical and Macromolecular Chemistry,RWTH Aachen University,52074,Aachen,Germany [3]College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai,201620,China [4]CQM-Centro de Química da Madeira,Universidade da Madeira,Campus da Penteada,9000-390,Funchal,Portugal [5]Department of Gynecology and Obstetrics,XinHua Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,200092,China [6]Aachen Maastricht Institute for Biobased Materials,Maastricht University,NL-6167 RD,Geleen,the Netherlands

出　　处：《Bioactive Materials》2021年第10期3244-3253,共10页生物活性材料（英文）

基　　金：This research was financially supported by the Sino-German Center for Research Promotion(GZ1505),DFG(SFB 985,Functional Microgels and Microgel Systems),National Natural Science Foundation of China(81801704 and 81761148028);Science and Technology Commission of Shanghai Municipality(18520750400);Shanghai Sailing Program(18YF1415300)。

摘　　要：Nanomedicine has revolutionized disease theranostics by the accurate diagnosis and efficient therapy.Here,the PAMAM dendrimer decorated PVCL-GMA nanogels(NGs)were developed for favorable biodistribution in vivo and enhanced antitumor efficacy of ovarian carcinoma.By an ingenious design,the NGs with a unique structure that GMA-rich domains were localized on the surface were synthesized via precipitation polymerization.After G2 dendrimer decoration,the overall charge is changed from neutral to positive,and the NGs-G2 display the whole charge nature of positively charged corona and neutral core.Importantly,the unique architecture and charge conversion of NGs-G2 have a profound impact on the biodistribution and drug delivery in vivo.As a consequence of this alteration,the NGs-G2 as nanocarriers emerge the highly sought biodistribution of reduced liver accumulation,enhanced tumor uptake,and promoted drug release,resulting in the significantly augmented antitumor efficacy with low side effects.Remarkably,this finding is contrary to some reported work that the nanocarriers with positive charge have preferential liver uptake.Moreover,the NGs-G2 also displayed thermal/pH dual-responsive behaviors,excellent biocompatibility,improved cellular uptake,and stimuli-responsive drug release.Encouragingly,this work demonstrates a novel insight into the strategy for optimizing design,improving biodistribution and enhancing theranostic efficacy of nanocarriers.

关 键 词：NANOGELS DENDRIMER Surface charge Thermal/pH dual-responsiveness Drug delivery 

分 类 号：R318[医药卫生—生物医学工程] R737.31[医药卫生—基础医学]