The recent advances in scaffolds for integrated periodontal regeneration  

作　　者：Hyun Nyun Woo Young Joon Cho Solaiman Tarafder Chang H.Lee 

机构地区：[1]Center for Dental and Craniofacial Research,Columbia University Medical Center,630 W.168 St.,VC12-212,New York,NY,10032,USA

出　　处：《Bioactive Materials》2021年第10期3328-3342,共15页生物活性材料（英文）

基　　金：This manuscript was in part supported by National Institutes of Health grant 1R01DE029321-01A1 to C.H.L.

摘　　要：The periodontium is an integrated,functional unit of multiple tissues surrounding and supporting the tooth,including but not limited to cementum(CM),periodontal ligament(PDL)and alveolar bone(AB).Periodontal tissues can be destructed by chronic periodontal disease,which can lead to tooth loss.In support of the treatment for periodontally diseased tooth,various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration(GTR)that is the current gold standard in dental clinic.Recently,various biomaterials have been prepared in a form of tissue engineering scaffold to facilitate the regeneration of damaged periodontal tissues.From a physical substrate to support healing of a single type of periodontal tissue to multi-phase/bioactive scaffold system to guide an integrated regeneration of periodontium,technologies for scaffold fabrication have emerged in last years.This review covers the recent advancements in development of scaffolds designed for periodontal tissue regeneration and their efficacy tested in vitro and in vivo.Pros and Cons of different biomaterials and design parameters implemented for periodontal tissue regeneration are also discussed,including future perspectives.

关 键 词：PERIODONTIUM PERIODONTITIS Bioactive scaffold Multi-phase scaffold Periodontal regeneration 

分 类 号：R318[医药卫生—生物医学工程] R78[医药卫生—基础医学]