Modulating degradation of sodium alginate/bioglass hydrogel for improving tissue infiltration and promoting wound healing  

作　　者：Xin Zhang Ying Li Zhijie Ma Dan He Haiyan Li 

机构地区：[1]School of Biomedical Engineering,Shanghai Jiao Tong University,1954 Huashan Road,Shanghai,200030,China [2]Chemical1nd Environmental Engineering,School of Engineering,RMIT University,124 La Trobe St,Melbourne,VIC,3000,Australia

出　　处：《Bioactive Materials》2021年第11期3692-3704,共13页生物活性材料（英文）

基　　金：the Natural Science Foundation of China(grant No.31771024 and 31971274);the Interdisciplinary Program of Shanghai Jiao Tong University(project number:ZH2018ZDA20).

摘　　要：More and more studies have recognized that the nanosized pores of hydrogels are too small for cells to normally grow and newly formed tissue to infiltrate,which impedes tissue regeneration.Recently,hydrogels with macropores and/or controlled degradation attract more and more attention for solving this problem.Sodium alginate/Bioglass(SA/BG)hydrogel,which has been reported to be an injectable and bioactive hydrogel,is also limited to be used as tissue engineering scaffolds due to its nanosized pores.Therefore,in this study,degradation of SA/BG hydrogel was modulated by grafting deferoxamine(DFO)to SA.The functionalized grafted DFO-SA(G-DFO-SA)was used to form G-DFO-SA/BG injectable hydrogel.In vitro degradation experiments proved that,compared to SA/BG hydrogel,G-DFO-SA/BG hydrogel had a faster mass loss and structural disintegration.When the hydrogels were implanted subcutaneously,G-DFO-SA/BG hydrogel possessed a faster degradation and better tissue infiltration as compared to SA/BG hydrogel.In addition,in a rat full-thickness skin defect model,wound healing studies showed that,G-DFO-SA/BG hydrogel significantly accelerated wound healing process by inducing more blood vessels formation.Therefore,G-DFO-SA/BG hydrogel can promote tissue infiltration and stimulate angiogenesis formation,which suggesting a promising application potential in tissue regeneration.

关 键 词：Sodium alginate BIOGLASS Hydrogels degradation Tissue infiltration Wound healing 

分 类 号：R318.08[医药卫生—生物医学工程]