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Bone regeneration is a critical area in regenerative medicine,particularly in orthopedics,demanding effective biomedical materials for treating bone defects.45S5 bioactive glass(45S5 BG)is a promising material because...
National Natural Science Foundation of China (51935014,52165043, 82072084, 81871498);Jiang Xi Provincial Natural Science Foundation of China (20192ACB20005,2020ACB214004);The Provincial Key R&D Projects of Jiangxi (20201BBE51012);Guangdong Province Higher Vocational Colleges&Schools Pearl River Scholar Funded Scheme (2018);Shenzhen Science and Technology Plan Project (JCYJ20170817112445033);Innovation Team Project on University of Guangdong Province(2018GKCXTD001);Technology Innovation Platform Project of Shenzhen Institute of Information Technology 2020(PT2020E002);China Postdoctoral Science Foundation(2020M682114);Open Research Fund of Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology。
Biodegradable magnesium(Mg) and its alloy show huge potential as temporary bone substitute due to the favorable biocompatibility and mechanical compatibility. However, one issue deserves attention is the too fast degr...
The composite coatings of chitosan(CS)-bioglass^(■)(BG)-hydroxyapatite(HA)-halloysite nanotube(HNT)were investigated and produced via electrophoretic deposition(EPD)technique.The utilization of CS as a dispersing,ble...
the Natural Science Foundation of China(grant No.31771024 and 31971274);the Interdisciplinary Program of Shanghai Jiao Tong University(project number:ZH2018ZDA20).
More and more studies have recognized that the nanosized pores of hydrogels are too small for cells to normally grow and newly formed tissue to infiltrate,which impedes tissue regeneration.Recently,hydrogels with macr...
This work is supported by the Chinese National Natural Science Foundation of China(31600773);Zhejiang Provincial Natural Science Foundation of China(LY18C100002).
Large bone defect repair requires biomaterials that promote angiogenesis and osteogenesis.In present work,a nanoclay(Laponite,XLS)-functionalized 3D bioglass(BG)scaffold with hypoxia mimicking property was prepared by...
supported by the Natural Science Foundation of China(Grant No.31771024 and 31971274);the Interdisciplinary Program of Shanghai Jiao Tong University(Project Number:ZH2018ZDA20).
Recently,exosomes have been extensively applied in tissue regeneration.However,their practical applications are severely restricted by the limited exosome secretion capability of cells.Therefore,developing strategies ...
a National Research Foundation of Korea(NRF)grant funded by the Ministry of Science and ICT(2019R1C1C1002490,2018R1A2B3003446);by the Global Research Development Center Program(2018K1A4A3A01064257);by the Priority Research Center Program provided by the Ministry of Education(2019R1A6A1A11034536)。
Therapeutic options are quite limited in clinics for the successful repair of infected/degenerated tissues.Although the prevalent treatment is the complete removal of the whole infected tissue,this leads to a loss of ...
We thank Dr.Jorg Fellenberg for technical support and inspiring scientific discussion and Sebastian Wilkesmann and Frederike Hohenbild for their support in designing the figures;This study was funded by the research fund of the Heidelberg Orthopedic University Hospital.Dr.Fabian Westhauser is supported by the“Physician Scientist Program”-scholarship introduced by the Medical Faculty of the University of Heidelberg;This study contains parts of Sarah Isabelle Schmitz's doctoral thesis.
Bioactive glasses(BGs)are promising bone substitute materials.However,under certain circumstances BGs such as the well-known 45S5 Bioglass®(composition in wt%:45.0 SiO2,24.5 Na2O,24.5 CaO,6.0 P2O5)act cytotoxic due to...
Objective: To study the regulating effect of borosilicate bioglass extract on the osteoblast proliferation activity and osteogenesis signaling pathway function. Methods: Osteoblasts MG-63 were cultured and divided int...
Supported by the Key Scientific and Technological Projects of Jilin Province, China(No.20170204041GX), the National Natural Science Foundation of China(Nos.81400487, 51673190, 51673187), the State Scholarship Fund of China(No. 201506175119) and the Research Fund of Jilin University, China(Nos.3D516B703431, 3R2161193431).
The bioglass particles/poly(lactide-co-glycolide)(BG/PLGA) scaffold has been extensively explored for biomedical applications due to its excellent advantages of mechanical property and controllable degradation rat...