Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine  

作　　者：Dayane Maria Braz Nogueira Marcelie Priscila de Oliveira Rosso Daniela Vieira Buchaim Mariana Schutzer Ragghianti Zangrando Rogério Leone Buchaim 

机构地区：[1]Department of Prosthodontics and Periodontics,Bauru School of Dentistry,University of São Paulo,Bauru 17012-901,Brazil [2]Department of Biological Sciences,Bauru School of Dentistry,University of São Paulo,Bauru 17012-901,Brazil [3]Medical School,University Center of Adamantina,Adamantina 17800-000,Brazil [4]Postgraduate Program in Structural and Functional Interactions in Rehabilitation,Postgraduate Department,University of Marília,Marília 17525-902,Brazil

出　　处：《World Journal of Orthopedics》2024年第3期204-214,共11页世界骨科杂志（英文版）

摘　　要：Bone regeneration is a critical area in regenerative medicine,particularly in orthopedics,demanding effective biomedical materials for treating bone defects.45S5 bioactive glass(45S5 BG)is a promising material because of its osteoconductive and bioactive properties.As research in this field continues to advance,keeping up-to-date on the latest and most successful applications of this material is imperative.To achieve this,we conducted a comprehensive search on Pub-Med/MEDLINE,focusing on English articles published in the last decade.Our search used the keywords“bioglass 45S5 AND bone defect”in combination.We found 27 articles,and after applying the inclusion criteria,we selected 15 studies for detailed examination.Most of these studies compared 45S5 BG with other cement or scaffold materials.These comparisons demonstrate that the addition of various composites enhances cellular biocompatibility,as evidenced by the cells and their osteogenic potential.Moreover,the use of 45S5 BG is enhanced by its antimicrobial properties,opening avenues for additional investigations and applications of this biomaterial.

关 键 词：Biocompatible materials BIOGLASS Bone regeneration 

分 类 号：R681[医药卫生—骨科学] R318.08[医药卫生—外科学]