Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits  

作　　者：Dick Ho Kiu Chow Jiali Wang Peng Wan Lizhen Zheng Michael Tim Yun Ong Le Huang Wenxue Tong Lili Tan Ke Yang Ling Qin 

机构地区：[1]Musculoskeletal Research Laboratory,Department of Orthopaedics&Traumatology,The Chinese University of Hong Kong,Hong Kong SAR,China [2]Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory,Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong,Shatin,Hong Kong SAR,China [3]Institute of Metal Research,Chinese Academy of Sciences,Shenyang,China [4]School of Materials Science and Engineering,Dongguan University of Technology,Dongguan,China

出　　处：《Bioactive Materials》2021年第11期4176-4185,共10页生物活性材料（英文）

基　　金：Chinese Academy of Sciences-Croucher Funding Scheme for Joint Laboratory(CAS14303);partially supported by Theme-based Research Scheme(Ref No.T13-402/17-N);Collaborative Research Fund(Ref No.C4026-17W)from the University Grant Committee of the Hong Kong Special Administrative Region,China.

摘　　要：Displaced fractures of patella often require open reduction surgery and internal fixation to restore the extensor continuity and articular congruity.Fracture fixation with biodegradable magnesium(Mg)pins enhanced fracture healing.We hypothesized that fixation with Mg pins and their degradation over time would enhance healing of patellar fracture radiologically,mechanically,and histologically.Transverse patellar fracture surgery was performed on thirty-two 18-weeks old female New Zealand White Rabbits.The fracture was fixed with a pin made of stainless steel or pure Mg,and a figure-of-eight stainless steel band wire.Samples were harvested at week 8 or 12,and assessed with microCT,tensile testing,microindentation,and histology.Microarchitectural analysis showed that Mg group showed 12%higher in the ratio of bone volume to tissue volume at week 8,and 38.4%higher of bone volume at week 12.Tensile testing showed that the failure load and stiffness of Mg group were 66.9%and 104%higher than the control group at week 8,respectively.At week 12,Mg group was 60.8%higher in ultimate strength than the control group.Microindentation showed that,compared to the Control group,Mg group showed 49.9%higher Vickers hardness and 31%higher elastic modulus at week 8 and 12,respectively.At week 12,the new bone of Mg group remodelled to laminar bone,but those of the control group remained woven bone-like.Fixation of transverse patellar fracture with Mg pins and its degradation enhanced new bone formation and mechanical properties of the repaired patella compared to the Control group.

关 键 词：Patellar fracture Tension band wire Biodegradable implant OSTEOGENESIS MICROINDENTATION 

分 类 号：R318[医药卫生—生物医学工程] R68[医药卫生—基础医学]