Enzymatically-degradable hydrogel coatings on titanium for bacterial infection inhibition and enhanced soft tissue compatibility via a self-adaptive strategy  

作　　者：Jin Leng Ye He Zhang Yuan Bailong Tao Ke Li Chuanchuan Lin Kun Xu Maowen Chen Liangliang Dai Xuemin Li Tony Jun Huang Kaiyong Cai 

机构地区：[1]Key Laboratory of Biorheological Science and Technology,Ministry of Education,College of Bioengineering,Chongqing University,Chongqing,400044,China [2]Thomas Lord Department of Mechanical Engineering&Materials Science,Duke University,Durham,NC,27708,USA [3]Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing,Southwest University,Chongqing,400715,China [4]Institute of Medical Research,Northwestern Polytechnical University,Xi’an 710072,China [5]Innovative Drug Research Centre,School of Pharmaceutical Sciences,Chongqing University,Chongqing,401331,China

出　　处：《Bioactive Materials》2021年第12期4670-4685,共16页生物活性材料（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China(51825302,21734002&52021004);the State Key Project of Research and Development(Grant No.2016YFC1100300&2017YFB0702603).

摘　　要：Ideal percutaneous titanium implants request both antibacterial ability and soft tissue compatibility.ZnO structure constructed on titanium has been widely proved to be helpful to combat pathogen contamination,but the biosafety of ZnO is always questioned.How to maintain the remarkable antibacterial ability of ZnO and efficiently reduce the corresponding toxicity is still challenging.Herein,a hybrid hydrogel coating was constructed on the fabricated ZnO structure of titanium,and the coating was proved to be enzymatically-degradable when bacteria exist.Then the antibacterial activity of ZnO was presented.When under the normal condition(no bacteria),the hydrogel coating was stable and tightly adhered to titanium.The toxicity of ZnO was reduced,and the viability of fibroblasts was largely improved.More importantly,the hydrogel coating provided a good buffer zone for cell ingrowth and soft tissue integration.The curbed Zn ion release was also proved to be useful to regulate fibroblast responses such as the expression of CTGF and COL-I.These results were also validated by in vivo studies.Therefore,this study proposed a valid self-adaptive strategy for ZnO improvement.Under different conditions,the sample could present different functions,and both the antibacterial ability and soft tissue compatibility were finely preserved.

关 键 词：TITANIUM ZnO Hydrogel coatings ANTI-BACTERIA FIBROBLASTS Soft tissue compatibility 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]