Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes  

作　　者：WANG Xiao-He DAI Ce WANG Jun LIU Rui LI Lei YIN Zong-Sheng 

机构地区：[1]Department of Bone and Joint Surgery,Institute of Orthopedic Diseases,the First Affiliated Hospital,Jinan University,Guangzhou 510000,China [2]Department of Orthopedics,the First Affiliated Hospital of Anhui Medical University,Hefei 230000,China

出　　处：《Chinese Journal of Natural Medicines》2021年第10期741-749,共9页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81672161).

摘　　要：During the pathogensis of rheumatoid arthritis(RA),activated RA fibroblast-like synoviocytes(RA-FLSs)combines similar proliferative features as tumor and inflammatory features as osteoarthritis,which eventually leads to joint erosion.Therefore,it is imperative to research and develop new compounds,which can effectively inhibit abnormal activation of RA-FLSs and retard RA progression.Neohesperidin(Neo)is a major active component of flavonoid compounds with anti-inflammation and anti-oxidant properties.In this study,the anti-inflammation,anti-migration,anti-invasion,anti-oxidant and apoptosis-induced effects of Neo on RAFLSs were explored to investigate the underlying mechanism.The results suggested that Neo decreased the levels of interleukin IL-1β,IL-6,IL-8,TNF-α,MMP-3,MMP-9 and MMP-13 in FLSs.Moreover,Neo blocked the activation of the MAPK signaling pathway.Furthermore,treatment with Neo induced the apoptosis of FLSs,and inhibited the migration of FLSs.It was also found that Neo reduced the accumulation of reactive oxygen species(ROS)induced by TNF-α.Taken together,our results highlighted that Neo may act as a potential and promising therapeutic drug for the management of RA.

关 键 词：NEOHESPERIDIN Rheumatoid-arthritis Fibroblast-like synoviocytes INFLAMMATORY Oxidative stress MAPK 

分 类 号：R965[医药卫生—药理学]