癌症-神经科学的再认识及其在脑胶质瘤研究中的进展  

Recognition of cancer-neuroscience and its role in glioma research

作　　者：贺电 李婷[1] 唐爱伟 孙海涛[3] He Dian;Li Ting;Tang Aiwei;Sun Haitao(National Key Clinical Specialty,Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease,Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration,Neurosurgery Institute of Guangdong Province,Neurosurgery Center,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;Second Clinical Medical College,Southern Medical University,Guangzhou 510282,China;Department of Laboratory Medicine,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)

机构地区：[1]南方医科大学珠江医院神经外科中心,国家临床重点专科,脑血管病诊断与治疗教育部工程研究中心,广东省普通高校脑功能修复与再生重点实验室,广东神经外科研究所,广州510282 [2]南方医科大学第二临床医学院,广州510282 [3]南方医科大学珠江医院检验医学部,广州510282

出　　处：《中华神经医学杂志》2021年第10期1050-1053,共4页Chinese Journal of Neuromedicine

基　　金：南方医科大学珠江医院院长基金(yzjj2018rc03)。

摘　　要：随着肿瘤学和神经科学的发展,其交叉学科--癌症-神经科学也在近年来引起学者们的广泛关注。人们逐渐认识到神经元参与肿瘤微环境的形成并影响着肿瘤的发生发展,同样,肿瘤也会引起神经系统重塑及功能障碍。其中,中枢神经系统中最常见的恶性肿瘤--脑胶质瘤与神经元的相互关系更是在近几年来有了全新的认识。笔者现回顾性总结癌症-神经科学在脑胶质瘤研究中的最新进展,对神经元与脑胶质瘤细胞相互作用的机制进行系统综述。With the development of oncology and neuroscience,cancer-neuroscience,as their interdisciplinary subject,has also attracted widespread scholars'attention in recent years.People have gradually realized that neurons are involved in the formation of tumor microenvironment and affect the initiation and progression of tumor.Similarly,tumor can also cause nervous system remodeling and dysfunction.The relationship between glioma,as the most common malignant tumor in the central nervous system,and neurons have gained a new understanding.This review discusses the latest advance in cancer-neuroscience in the study of gliomas,and systematically reviews the mechanism of interaction between neurons and glioma cells.

关 键 词：癌症-神经科学 神经胶质瘤 神经元 突触 

分 类 号：R739.41[医药卫生—肿瘤]