慢性便秘的肠黏膜屏障功能研究进展  

Research Progress of Intestinal Mucosal Barrier Function in Chronic Constipation

作　　者：王君珂 姚树坤[2] WANG Junke;YAO Shukun(Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing 100730,China;Department of Gastroenterology,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中国医学科学院北京协和医学院,北京100730 [2]中日友好医院消化内科,北京100029

出　　处：《医学综述》2021年第20期4070-4075,共6页Medical Recapitulate

摘　　要：慢性便秘是临床常见的消化系统疾病,病理生理机制复杂,具体发病机制尚未阐明。肠黏膜屏障由上皮前、上皮以及上皮后成分三部分组成,防止腔内致病性抗原(细菌、有毒物质等)侵入黏膜下组织,同时能选择性滤过营养物质以及水分子,在维持机体内环境稳态以及正常生命活动中发挥重要作用。慢性便秘患者存在肠黏膜屏障结构的改变,进而导致黏膜通透性增加以及屏障功能受损,并通过影响肠道动力、肠道感觉以及肠道免疫状态参与便秘发病,但其内在分子机制仍有待进一步研究。Chronic constipation is a common digestive system disease in the clinics,with complicated pathophysiological mechanisms,and unclarified specific pathogenesis.Intestinal mucosal barrier consists of three parts:anterior epithelium,epithelium and posterior epithelium,which prevent pathogenic antigens(bacteria,toxic substances,etc.)in the lumen from invading submucosal tissues and selectively filter nutrients and water molecules,playing an important role in maintaining the body homeostasis and normal life activities.The patients with chronic constipation have changes in intestinal mucosal barrier structures,which results in increased mucosal permeability and impaired barrier function,and is involved in the onset of constipation by affecting intestinal motility,intestinal sensation and intestinal immune status,whereas the internal molecular mechanisms remain to be further studied.

关 键 词：慢性便秘 肠黏膜屏障 肠黏膜通透性 

分 类 号：R574.4[医药卫生—消化系统]