醒脑静联合化痰通络汤治疗急性缺血性脑卒中临床疗效  

Clinical Research on Treatment of Acute Ischemic Stroke with Xingnaojing Combined Huatan Tongluo Decoction

作　　者：王正 贾开红 周晓卿[3] WANG Zheng;JIA Kaihong;ZHOU Xiaoqing(Henan General Hospital,Henan Zhengzhou 450000,China;Traditional Chinese Medicine Hospital of Zhengzhou,Henan Zhengzhou 450002,China;Shenzhen Hospital of Beijing University of Chinese Medicine,Guangdong Shenzhen 518100,China)

机构地区：[1]河南省职工医院,河南郑州450000 [2]郑州市中医院,河南郑州450002 [3]北京中医药大学深圳医院,广东深圳518100

出　　处：《中医药临床杂志》2021年第10期1970-1973,共4页Clinical Journal of Traditional Chinese Medicine

摘　　要：目的:观察醒脑静联合化痰通络汤治疗急性缺血性脑卒中(风痰瘀阻型)的有效性及安全性。方法:收集2015年12月—2017年12月郑州市中医院脑病科住院的风痰瘀阻型急性缺血性脑卒中患者共65例,将其随机分为对照组(32例)和治疗组(33例),2组患者均按《2014中国急性缺血性卒中诊治指南》给予常规西医治疗;治疗组在此基础上加用醒脑静注射液及化痰通络汤。2组患者分别于入组前、第7天,第14天采用中医症候积分、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)、改良Rankin 量表(Modified Rankin scale,mRS)、改良Barthel指数(Modified Barthel index,MBI)评估患者神经功能缺损程度、生活质量、日常生活能力等指标。结果:治疗组有效率为96.9%,对照组有效率为81.3%,治疗组优于对照组;2组患者中医症候均得到改善,并且治疗组优于对照组;在治疗第7天及第14天时NIHSS评分比较,治疗组优于对照组,差异均有统计学意义;治疗第7天进行mRS评分、MBI评分比较时,2组差异无统计学意义,第14天时治疗组优于对照组,差异有统计学意义。结论:醒脑静注射液联合化痰通络汤治疗风痰瘀阻型急性缺血性脑卒中安全有效,能够明显改善患者的神经功能缺损程度,提高患者的日常生活活动能力及生活质量。Objective:To observe the effectiveness and safety of Xingnaojing combined with Huatan Tongluo Decoction in the treatment of acute ischemic stroke (wind,phlegm and blood stasis).Methods:A total of 65 patients with acute ischemic stroke of wind phlegm and blood stasis type who were hospitalized in the Department of Brain Diseases,Zhengzhou Hospital of Traditional Chinese Medicine from December 2015 to December 2017 were collected,and they were randomly divided into control group (32 cases) and treatment group (33 cases).Patients in both groups were treated with conventional Western medicine in accordance with the “2014 Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke in China”;the treatment group was additionally given Xingnaojing Injection and Huatan Tongluo Decoction on this basis.The two groups of patients were treated with TCM syndrome scores,National Institutes of Health Stroke Scale (NIHSS),and Modified Rankin scale (mRS) before enrollment,on the 7th day and the 14th day.),modified Barthel index (Modified Barthel index,MBI) to assess the degree of neurological impairment,quality of life,ability of daily living and other indicators of patients.Results:The effective rate of the treatment group was 96.9%,and the effective rate of the control group was 81.3%.The treatment group was better than the control group;the TCM symptoms of the two groups were improved,and the treatment group was better than the control group;on the 7th and 14th day of treatment When comparing NIHSS scores on the first day,the treatment group was better than the control group,and the difference was statistically significant.When comparing the mRS score and MBI score on the 7th day of treatment,the difference between the two groups was not statistically significant.The treatment group was better than the control group on the 14th day.The difference was statistically significant.Conclusion:Xingnaojing injection combined with Huatan Tongluo Decoction is safe and effective in treating acute ischemic stroke of wind phlegm

关 键 词：急性缺血性脑卒中 醒脑静注射液 化痰通络汤 风痰瘀阻证 疗效评价 

分 类 号：R743.3[医药卫生—神经病学与精神病学]