乳腺癌患者术后再发甲状腺癌的影响因素分析  

Influencing Factors of Secondary Thyroid Cancer in Breast Cancer Patients after Surgery

作　　者：张琦 董晓寅 黄桂林[2] ZHANG Qi;DONG Xiao-yin;HUANG Gui-lin(Shihezi Univerisity School of Medicine,Xinjiang Shihezi,832002;Department of General Surgery,the First Affiliated Hospital of Shihezi University School of Medicine,Xinjiang Shihezi,832008)

机构地区：[1]石河子大学医学院,新疆石河子832002 [2]石河子大学医学院第一附属医院普外科,新疆石河子832008

出　　处：《农垦医学》2021年第4期338-340,350,共4页Journal of Nongken Medicine

摘　　要：目的:观察乳腺癌术后再发甲状腺癌患者的临床特点,对可能影响乳腺癌患者术后再发甲状腺癌的相关因素进行分析。方法:收集2014年1月-2020年6月就诊于石河子大学医学院第一附属医院乳腺癌患者的病例资料,按照术后有无再发甲状腺癌分为病例组(18名):乳腺癌术后再发甲状腺癌组(A组)和对照组(50名):单纯乳腺癌组(B组),分别记录两组患者的年龄、生育次数、免疫组化指标、癌胚抗原、血脂指标及有无放射治疗史。结果:乳腺癌术后再发甲状腺癌组和单纯乳腺癌组患者的乳腺癌雌激素受体(ER)、孕激素受体(PR)状态和术后是否放疗差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,ER(+)[OR(95%CI):8.023(1.871-34.405)]、PR(+)[OR(95%CI):7.603(1.469-39.358)]、放疗[OR(95%CI):5.853(1.084-31.596)]是乳腺癌术后再发甲状腺癌的独立危险因素。结论:雌激素受体和孕激素受体阳性、放疗可能促进乳腺癌术后患者再发甲状腺癌。Objective:To observe the clinical characteristics of patients with recurrent thyroid cancer after breast cancer operation,and to analyze the related factors that may affect the recurrence of thyroid cancer after breast cancer operation.Methods:Collecting the imformation of patients who were diagnosed as breast cancer in the first affiliated hospital of Shihezi University school of medicine from January 2014 to June 2020,according to the cases with or without postoperative recurrence thyroid carcinoma,the cases were divided into case group(18):Thyroid cancer recurrent after breast cancer surgery group(group A)and control group(50):pure breast cancer group(group B),record the datas of the two groups such as patient's age,the times of birth,immunohistochemical index,carcinoembryonic antigen and blood lipids index,and presence of history of radiation therapy.Results:When it comes to estrogen receptor(ER)and progesterone receptor(PR)status and postoperative radiotherapy,the difference between thyroid cancer recurrent after breast cancer surgery group and pure breast cancer group was statistically significant(P<0.05),the multi-factor Logistic regression analysis results showed that the ER(+)[OR(95%CI):8.023(1.871~34.405)],PR(+)[OR(95%CI):7.603(1.469~39.358)],radiotherapy[OR(95%CI):5.853(1.084~31.596)]are independent risk factors for recurrent thyroid cancer after breast cancer surgery.Conclusion:Positive estrogen receptor and progesterone receptor and radiotherapy may promote the recurrence of thyroid cancer in postoperative breast cancer patients.

关 键 词：乳腺癌 甲状腺癌 影响因素 

分 类 号：R737.9[医药卫生—肿瘤] R736.1[医药卫生—临床医学]