脑梗死患者认知功能恢复与患者炎症因子及Rho激酶表达的关系  

The relationship between cognitive function recovery and inflammation factors and Rho kinase expression in patients with cerebral infarction

作　　者：黄亮[1] 张思磊 朱作磊 靖雄飞 余兴 艾威 姜韦华 HUANG Liang;ZHANG Si-lei;ZHU Zuo-lei(Department of Neurosurgery,Xiantao First People's Hospital Affiliated to Yangtze University,Xiantao Hubei 433000,China)

机构地区：[1]长江大学附属仙桃市第一人民医院神经外科,湖北仙桃433000 [2]青岛福山康复医院神经康复科,山东青岛260035

出　　处：《临床和实验医学杂志》2021年第19期2064-2067,共4页Journal of Clinical and Experimental Medicine

基　　金：湖北省自然科学基金(编号:WJ2015M075)。

摘　　要：目的探究脑梗死患者认知功能恢复与患者炎症因子及Rho激酶表达的关系。方法前瞻性选取2017年6月至2020年6月长江大学附属仙桃市第一人民医院收治的70例脑梗死患者作为研究对象,参考蒙特利尔认知评估量表,低于15分纳入未恢复组(n=32),高于15分纳入恢复组(n=38)。收集2组脑梗死患者外周血,检测炎症因子[白细胞介素(IL)-1β、IL-4、IL-6、肿瘤坏死因子α(TNF-α)]、免疫相关指标(IgA、IgG、IgM)水平差异,并检测血清Rho激酶表达情况,分析Rho激酶表达与Barthel指数、斯堪地那维亚卒中量表(SSS)、简易智力状态检查(MMSE)评分的相关性。结果恢复组和未恢复组性别、年龄分布差异无统计学意义(P>0.05),恢复组溶栓时间≤5 h和NIHSS评分>15分的患者比率(65.79%、71.05%)显著高于未恢复组(50.00%、46.88%),差异均有统计学意义(P<0.05)。恢复组Barthel指数和MMSE评分为(54.24±4.39)、(22.38±2.48)分,明显高于未恢复组[(32.83±3.29)、(15.84±1.47)分],SSS评分为(12.37±2.24)分,明显低于未恢复组[(17.38±1.37)分],差异均有统计学意义(P<0.05)。恢复组患者IL-1β、IL-4、TNF-α水平为(14.21±2.31)、(12.48±3.84)、(9.28±0.84)ng/L,均明显低于未恢复组[(18.38±3.48)、(14.28±5.35)、(16.93±1.64)ng/L],差异均有统计学意义(P<0.05),而IL-6水平差异无统计学意义(P>0.05)。恢复组患者IgA、IgG水平为(89.22±7.28)、(78.42±8.48)U/mL,均明显低于未恢复组[(110.24±10.24)、(174.21±15.45)U/mL],差异均有统计学意义(P<0.05),而IgM水平差异无统计学意义(P>0.05)。恢复组Rho激酶的浓度为(69.89±6.90)μg/L,明显低于未恢复组[(122.62±12.31)μg/L],差异有统计学意义(P<0.001)。Rho激酶表达水平与脑梗死患者Barthel指数、MMSE评分有显著的负相关性(r=-0.472、-0.584,P=0.022、0.014),与脑梗死患者SSS评分有显著的正相关性(r=0.723,P<0.001)。结论脑梗死患者认知功能恢复与炎症因子、免疫指标、Rho激�Objective To explore the relationship between the recovery of cognitive function in patients with cerebral infarction,inflammation factors and the expression of Rho kinase.Methods Seventy patients with cerebral infarction admitted to Xiantao First People's Hospital of Yangtze University from June 2017 to June 2020 were prospectively selected as the research objects.Referring to the Montreal Cognitive Assessment Scale,scores below 15 were included in the unrecovered group(n=32),scores higher than 15 were included in the recovery group(n=38).The peripheral blood of the two groups of patients was collected,and the levels of inflammatory factors[interleukin(IL)-1β,IL-4,IL-6,tumor necrosis factor alpha(TNF-α)],immune-related indicators(IgA,IgG,IgM)were tested and compared.The correlation between Rho kinase expression and Barthel index,Scandinavian Stroke Scale(SSS),Mini-mental State Examination(MMSE)score was analyzed.Results There was no statistical difference in gender and age distribution between the recovery group and the unrecovered group(P>0.05).The proportion of patients with cerebral infarction with thrombolysis time≤5 hours and NIHSS score>15 points in the recovery group(65.79%,71.05%)were significantly higher than those in the non-recovery group(50.00%,46.88%),and the differences were statistically significant(P<0.05).The Barthel index and MMSE score in the recovery group were(54.24±4.39)and(22.38±2.48)points,which were significantly higher than those in the non-recovery group[(32.83±3.29),(15.84±1.47)points],and the SSS score was(12.37±2.24)points,which was significantly lower than that in the unrecovered group[(17.38±1.37)points],the differences were statistically significant(P<0.05).The levels of IL-1β,IL-4 and TNF-αin the recovery group were(14.21±2.31),(12.48±3.84),(9.28±0.84)ng/L,which were significantly lower than those in the non-recovery group[(18.38±3.48),(14.28±5.35),(16.93±1.64)ng/L],the differences were statistically significant(P<0.05),there was no statistically significant di

关 键 词：脑梗死 认知功能 炎症因子 RHO激酶 

分 类 号：R743.33[医药卫生—神经病学与精神病学]