诺贝尔生理学或医学奖的明星分子TRPV1受体参与慢性疼痛  

TRPV1,a star molecule of Nobel Prize in Physiology or Medicine,participates in chronic pain

作　　者：刘风雨[1,2,3] 万有[1,2,3] LIU Fengyu;WAN You(Neuroscience Research Institute,Peking University;Department of Neurobiology,School of Basic Medical Sciences,Peking University;Key Laboratory for Neuroscience,Ministry of Education/National Health Commission,Beijing 100191,China)

机构地区：[1]北京大学神经科学研究所 [2]北京大学基础医学院神经生物学系 [3]神经科学教育部重点实验室/国家卫生健康委员会神经科学重点实验室,北京100191

出　　处：《中国疼痛医学杂志》2021年第10期733-736,共4页Chinese Journal of Pain Medicine

基　　金：国家自然科学基金委项目(32171002,81974166,30570566);国家重点研发计划(2017YFA0701302);北京大学医学科技创新平台发展基金-医学交叉种子基金资助项目(BMU2021MX002)。

摘　　要：2021年诺贝尔生理学或医学奖揭晓。科学家大卫·朱利叶斯(David Julius)和阿登·帕塔普蒂安(Ardem Patapoutian)因为发现了“温度和触觉感受器”荣获该奖。作为疼痛领域的研究者,我们早在1999年就开始关注David Julius实验室在1997年克隆成功的辣椒素受体(现在统一命名为TRPV1受体)。TRPV1克隆成功以来,本实验室致力于研究TRPV1受体在慢性疼痛中的作用,主要学术贡献为:(1)率先提出了TRPV1受体在慢性炎性痛中的作用;(2)率先提出了TRPV1受体参与内源性甲醛导致慢性癌性疼痛及其调控的分子机制。期待科学家们以此为靶点,开发出高效低毒的药物,用以治疗慢性疼痛等疾病。The Nobel Prize in Physiology or Medicine 2021 was awarded jointly to David Julius and Ardem Patapoutian for their discoveries of"receptors for temperature and touch".Transient receptor potential vanilloid 1(TRPV1)is a non-selective cation channel gated by noxious heat,proton and capsaicin,which has been cloned successfully by David Julius in 1997.Since 1999,a series of investigations in our group focused on the role of TRPV1 in chronic pain.Our academic contributions mainly include two aspects:(1)TRPV1 participates in chronic inflammatory pain;(2)TRPV1 plays important roles in cancer pain,especially it is activated by tumor tissue-derived endogenous formaldehyde and up-regulated by insulin-like growth factor-I(IGF-I).We hope new drugs based on TRPV1 will be developed to treat diseases like chronic pain.

关 键 词：辣椒素受体 慢性炎症痛 骨癌痛 甲醛 诺贝尔生理学或医学奖 

分 类 号：R402[医药卫生—临床医学]