线粒体相关内质网膜:心血管疾病治疗的新靶点  

Mitochondria-associated ER membranes:a new target for the treatment of cardio-vascular diseases

作　　者：董博文 王子同 于雪[1] 李弘[1] 杨力明[1] DONG Bowen;WANG Zitong;YU Xue;LI Hong;YANG Liming(Harbin Medical University,Harbin,Heilongjiang 150081,China)

机构地区：[1]哈尔滨医科大学,黑龙江省哈尔滨市150081

出　　处：《中国动脉硬化杂志》2021年第12期1013-1020,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金资助项目(91939104、82070465和82170469);黑龙江省自然科学基金杰出青年项目(JQ2021H001);心血管疾病国家重点实验室开放课题资助项目(2019kf-02);心肌缺血教育部重点实验室开放课题资助项目(KF201908);黑龙江省卫生健康委面上项目(2020-075)。

摘　　要：线粒体相关内质网膜是指内质网和线粒体之间高度动态的紧密连接部分,参与维持内质网和线粒体的正常功能,与细胞脂质代谢、钙稳态、线粒体动力学、自噬和凋亡、内质网应激和炎症等密切相关。研究显示线粒体相关内质网膜功能异常或者数量和结构改变参与心血管疾病的发生发展。本文总结了线粒体相关内质网膜的功能,阐述了其在心血管疾病中的作用及可能机制,为线粒体相关内质网膜成为心血管疾病治疗的新靶点提供理论参考。The highly dynamic tight junctions between the endoplasmic reticulum and mitochondria are known as mitochondria-associated ER membranes.These domains are essential for basic biological processes,including lipid metabolism,calcium homeostasis,mitochondrial dynamics,autophagy and apoptosis,endoplasmic reticulum stress and inflammation.Many studies have proved the abnormal amount,structure or function of mitochondria-associated ER membranes are related to the occurrence and development of cardiovascular diseases.This paper summarized the functions of mitochondria-associated ER membranes and its roles and possible mechanism in cardiovascular diseases,and provided theoretical references for mitochondria-associated ER membranes to become new targets for cardiovascular therapy.

关 键 词：线粒体相关内质网膜 心血管疾病 自噬 炎症 钙离子 细胞凋亡 活性氧自由基 

分 类 号：R5[医药卫生—内科学]