血清7种自身抗体检测对肺癌的诊断价值  

Diagnostic Value of Seven Serum Autoantibodies in Lung Cancer

作　　者：王耀娟 高菲[1] 于亮[2] 马刚[3] 韩育宁[2] 张锦[3] 张淑香[3] WANG Yaojuan;GAO Fei;YU Liang;MA Gang;HAN Yuning;ZHANG Jin;ZHANG Shuxiang(Ningxia Medical University,Yinchuan 750004,China;Department of Thoracic Surgery,the General Hospital of Ningxia Medical University,Yinchuan 750004,China;Department of Respiratory and Critical Care Medicine,the General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学总医院胸外科,银川750004 [3]宁夏医科大学总医院呼吸与危重症医学科,银川750004

出　　处：《宁夏医科大学学报》2021年第10期996-999,1003,共5页Journal of Ningxia Medical University

基　　金：国家重点研发计划资助项目(2017YFC0909900);宁夏呼吸系统疾病临床医学研究中心开放课题

摘　　要：目的探讨7种肿瘤相关自身抗体(P53、PGP9.5、SOX2、GAGE7、GBU4-5、MAGEA1、CAGE)对肺癌的临床诊断价值。方法纳入经病理学确诊的肺癌患者77例(肺癌组)和肺部良性病变患者33例(对照组),采用酶联免疫吸附(ELISA)法检测两组患者的自身抗体浓度,采用多变量方差检验比较两组患者自身抗体浓度差异,绘制ROC曲线分析7种自身抗体对肺癌的诊断效能,比较不同病理类型、分期、病灶大小肺癌患者的自身抗体阳性率。结果肺癌组患者P53、GAGE7和MAGEA1抗体水平均高于对照组(P均<0.05)。肺癌组患者7种自身抗体联合检测阳性率高于对照组(P<0.05)。单个自身抗体诊断肺癌的灵敏度低,特异度为87.88%~100.00%。7种自身抗体联合诊断肺癌的灵敏度为49.35%,特异度为81.82%,ROC曲线下面积(AUC)为0.795。7种自身抗体的表达与肺癌的病理类型、临床分期及病灶大小均无关。结论血清7种自身抗体联合检测对肺癌诊断的特异度较高。Objective To investigate the clinical diagnostic value of seven tumor-related autoantibodies(P53,PGP9.5,SOX2,GAGE7,GBU4-5,MAGEA1,CAGE)in lung cancer.Methods A total of 77 patients with lung cancer and 33 patients with benign pulmonary lesions diagnosed by pathology were included in our hospital.The concentration of autoantibodies in the two groups was detected by enzyme-linked immunosorbent assay(ELISA).The difference of autoantibody concentration between the two groups was compared by multivariate variance test,and the ROC curve was drawn to analyze the diagnostic efficacy of seven autoantibodies in lung cancer.The positive rates of autoantibodies in patients with lung cancer with different pathological types,stages and lesions were compared.Results The levels of P53,GAGE7 and MAGEA1 antibodies in patients with lung cancer were significantly higher than those in patients with benign pulmonary lesions(P all<0.05).The positive rate of combined detection of seven autoantibodies in patients with lung cancer was significantly higher than that in patients with benign pulmonary lesions(P<0.05).The sensitivity of single autoantibody was low,and the specificity fluctuated from 87.88%to 100.00%.The sensitivity and specificity of combined diagnosis of seven autoantibodies were 49.35%and 81.82%,respectively,and the quotient AUC was0.795.There was no correlation between the expression of seven autoantibodies and the pathological type,clinical stage and lesion size of lung cancer.Conclusion The combined detection of seven autoantibodies in serum has high specificity in the diagnosis of lung cancer.

关 键 词：自身抗体 肺癌 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤]