粪菌移植途径的临床应用现状  

Clinical application of fecal bacteria transplantation approaches

作　　者：周小珏 冯婧 张安仁 庞日朝 ZHOU Xiao-jue;FENG Jing;ZHANG An-ren;PANG Ri-chao(Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610075,China;不详)

机构地区：[1]成都中医药大学,四川成都610075 [2]中国人民解放军西部战区总医院康复医学科

出　　处：《中国微生态学杂志》2021年第9期1104-1108,共5页Chinese Journal of Microecology

基　　金：国家自然科学基金(8197151951);四川省卫生和计划生育委员会科研课题(18PJ509)。

摘　　要：人体肠道内寄居着数量庞大、种类繁多的微生物,形成肠道微生态稳态,而肠道微生态失衡与多种肠内、肠外疾病相关。随着人们对肠道菌群在宿主健康及疾病中作用的深入认识,粪菌移植(faecal microbiota transplantation, FMT)被给予厚望,其作为重建肠道菌群的有效手段,已成功应用于艰难梭菌感染(Clostridioides difficile infection, CDI)等疾病的治疗和探索性研究,并被认为是近年的突破性医学进展。随着近几年FMT研究的深入,人们发现FMT对各系统疾病皆有潜在的治疗作用。在1990年之前,菌群移植都是经灌肠实施,近几年随着粪菌移植研究的深入,粪菌移植途径也呈多样化发展。本文对粪菌移植途径、临床应用和存在的问题等作一综述。There are a large number and various kinds of microorganisms in the human intestinal tract, forming intestinal microecological homeostasis, and intestinal microecological imbalance is related to a variety of intestinal and parenteral diseases. Through the detection of fecal microorganisms, the study on the influences of intestinal microbes on human health and diseases has made certain progress.Faecal microbiota transplantation(FMT), as a new treatment, had been included in the clinical guidelines for treatment options of Clostridium difficile infection in 2013. With the progress in study on FMT in recent years, it has been found that FMT has a potential therapeutic effect on all diseases of the system. Before 1990, bacterial transplantation was carried out through enema. In recent years, with further study on FMT, the approach of FMT has been diversified.

关 键 词：粪菌移植 艰难梭菌感染 经内镜肠管移植 炎症性肠病 肠易激综合征 

分 类 号：R574[医药卫生—消化系统]