肝癌人源肿瘤异种移植模型的应用研究进展  

Current status and perspectives of patient-derived xenograft models in liver cancer research

作　　者：蒋林含 谭晓霞 李俊 苏松 李亚玲 Jiang Lin-Han;Tan Xiao-Xia;Li Jun;Su Song;Li Ya-Ling(Department of Pharmacy,the Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China;School of Pharmacy,Southwest Medical University,Luzhou,Sichuan 646000,China;Department of Chinese Traditional Medicine,the Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China;Department of Hepatobiliary Surgery,the Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China)

机构地区：[1]西南医科大学附属医院药学部,四川泸州646000 [2]西南医科大学药学院,四川泸州646000 [3]西南医科大学附属医院中医科,四川泸州646000 [4]西南医科大学附属医院肝胆外科,四川泸州646000

出　　处：《解放军医学杂志》2021年第10期1029-1033,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81803019)。

摘　　要：肝癌人源肿瘤异种移植(PDX)模型是将肝癌患者的原发肿瘤组织移植到免疫缺陷小鼠体内,能较好地模拟原代肿瘤的生物学特性及与患者相似的遗传特性和肿瘤异质性,已广泛用于肝癌研究,在药物研究、临床肿瘤治疗中具有重要地位。该文总结了国内外建立肝癌PDX模型的方法,概述了4种新型肝癌PDX模型,回顾了肝癌PDX模型在基础研究与临床前研究中的应用现状,以期为肝癌研究提供新的视角并为后续研究提供参考。Patient-derived xenograft (PDX) model of liver cancer is created by transplanting the primary tumor tissue of patients with liver cancer into immunodeficient mice to simulate the biological characteristics of primary tumors,similar genetic characteristics and tumor heterogeneity with patients,which has been widely used in liver cancer research and plays an important role in drug research and clinical tumor treatment.This review firstly summarize the methodology to establish PDX models of liver cancer,four new PDX models of live cancer,and then go over recent application and function of liver cancer PDX models in basic cancer research and in preclinical explorations and finally give our perspectives on the future prospects of liver cancer PDX models.

关 键 词：肝癌 人源肿瘤异种移植模型 基础研究 临床前研究 药物评估 

分 类 号：R735.7[医药卫生—肿瘤]