sVAP-1联合ABCD3-I评分对短暂性脑缺血发作后急性脑梗死的预测价值  

Soluble vascular adhesion protein 1 combined with ABCD3-I score in predict-ing acute cerebral infarction after transient ischemic attack

作　　者：李娜[1] 张俊霞 吉维忠[1] 吴芬香[1] 李沛[1] 马玉青[1] LI Na;ZHANG Junxia;JI Weizhong;WU Fenxiang;LI Pei;MA Yuqing(Department of Neurology,Qinghai Provincial People's Hospital,Xining 810007,China;Department of Neurology,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430077,China)

机构地区：[1]青海省人民医院神经内科,西宁810007 [2]华中科技大学同济医学院附属梨园医院神经内科,武汉430077

出　　处：《新疆医科大学学报》2021年第11期1265-1269,共5页Journal of Xinjiang Medical University

基　　金：青海省科技计划项目(2020-ZJ-757)。

摘　　要：目的研究可溶性血管黏附蛋白1(sVAP-1)联合ABCD3-I评分对短暂性脑缺血发作(TIA)后急性脑梗死(ACI)的预测价值。方法选取2016年1月—2019年1月青海省人民医院神经内科接诊的TIA患者90例,随访2年,根据是否发生ACI分为ACI组、非ACI组。比较两组血清sVAP-1水平、ABCD3-I评分及其他可能影响因素的差异;采用Logistic回归分析法分析TIA后发生ACI的影响因素;绘制受试者工作曲线(ROC),评价sVAP-1联合ABCD3-I评分对TIA后发生ACI的预测价值。结果随访过程中8例患者失访,82例患者中发生ACI共计32例(39.02%),设为ACI组,其余50例设为非ACI组。与非ACI组比较,ACI组心脏病患者构成比、TIA发作频率、血清sVAP-1水平、ABCD3-I评分较高,TIA持续时间较长(P<0.05);Logistic回归分析法显示,高sVAP-1、高ABCD3-I评分均是TIA后发生ACI的危险因素(P<0.05);ROC曲线显示,sVAP-1、ABCD3-I预测TIA后发生ACI的最佳截断点分别为79.19 ng/mL、7.15分,两者单独及联合预测的ROC曲线下面积(AUC)分别为0.778、0.788、0.844。结论TIA后ACI患者血清sVAP-1水平及ABCD3-I评分异常升高,两者联合对ACI的发生具有较高的预测价值。Objective To study the predictive value of soluble vascular adhesion protein 1(sVAP-1)combined with ABCD3-I score for acute cerebral infarction(ACI)after transient ischemic attack(TIA).Methods A total of 90 TIA pa⁃tients admitted to the Department of Neurology of Qinghai Provincial People’s Hospital from January 2016 to January 2019 were selected and followed up for 2 years.According to whether ACI occurred,they were divided into ACI group and non-ACI group.The differences in serum sVAP-1 levels,ABCD3-I scores and other possible influencing factors between the two groups were compared.Logistic regression analysis was used to analyze the influencing factors of ACI after TIA.The evaluate the predictive value of sVAP-1 combined with ABCD3-I score on the occurrence of ACI after TIA was evaluated by receiver operating curve(ROC).Results During the follow-up,8 patients lost to follow-up.A to⁃tal of 32 patients(39.02%)had ACI among 82 patients,which were set as the ACI group,and the remaining 50 pa⁃tients were set as the non-ACI group.Compared with the non-ACI group,the ratio of heart disease,the frequency of TIA attacks,the serum sVAP-1 level,and the ABCD3-I score of the ACI group were higher,of which the duration of TIA was longer(P<0.05).Logistic regression analysis showed that high sVAP-1 and high ABCD3-I scores were all risk factors for ACI after TIA(P<0.05).The ROC curve showed that the best cut-off points for ACI after TIA predicted by sVAP-1 and ABCD3-I were 79.19 ng/mL and 7.15 points,respectively.The area under the ROC curve(AUC)pre⁃dicted by both separately and jointly were 0.778,0.788,0.844,respectively.Conclusion The serum sVAP-1 level and ABCD3-I score of ACI patients increase abnormally after TIA.The combination of the two has a high predictive value for the occurrence of ACI.

关 键 词：可溶性血管黏附蛋白1 ABCD3-I评分 短暂性脑缺血 急性脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]