原发性眼眶黑色素瘤的研究进展  

Research progress on primary orbital melanoma

作　　者：王金锦 马建民 Wang Jinjin;Ma Jianmin(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology&Visual Sciences,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心,北京市眼科学与视觉科学重点实验室,100730

出　　处：《中华眼科杂志》2021年第11期861-864,共4页Chinese Journal of Ophthalmology

基　　金：北京市医院管理中心“登峰”计划专项(DFL20190201);北京市自然科学基金(7182038)。

摘　　要：原发性眼眶黑色素瘤(POM)是一种罕见的眼眶恶性肿瘤。POM的发生与原有的黑色素病变如眼皮肤黑色素细胞增多症、蓝痣等有关, 其最常见的临床表现为渐进性无痛性眼球突出。疾病的罕见性导致其诊断较为困难。MRI是诊断本病的重要方法, 组织病理学检查为诊断POM的金标准。治疗以手术切除为主, 辅以放射治疗、化学治疗等。本文主要回顾了POM的发病机制、临床表现、辅助检查、诊断以及治疗的进展, 将这一罕见疾病进行系统地总结, 以期为POM的研究提供参考。Primary orbital melanoma(POM)is a sort of extremely rare orbital malignancy.It often associates with melanin lesion such as congenital ocular melanocytosis and blue nevus.The most common clinical manifestation of POM is progressive painless proptosis.There are some difficulties in diagnosing this disease.MRI shows characteristic expression of this disease as an important way to diagnose POM,while pathology is the gold standard.Surgery is the mainstay of treatment in patients with POM.In addition,adjuvant radiotherapy and chemotherapy should be considered.This article systematically reviews the research progress of pathogenesis,clinical manifestation,auxiliary examination,differential diagnosis and treatment of POM,in order to provide some thoughts for the future study of the rare malignancy.

关 键 词：眶肿瘤 黑色素瘤 

分 类 号：R739.7[医药卫生—肿瘤]