A H_(2)S-triggered two-photon ratiometric fluorescent theranostic prodrug for bio-imaging  

作　　者：Xianghua Wu Yuxun Lu Bo Liu Yu Chen Junfeng Zhang Ying Zhou 

机构地区：[1]College of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming 650500,China [2]College of Chemical Science and Technology,Yunnan University,Kunming 650091,China

出　　处：《Chinese Chemical Letters》2021年第8期2380-2384,共5页中国化学快报（英文版）

基　　金：the support of the National Natural Science Foundation of China (Nos.21867019,22067021,22067019);the “Youth Talent of Wan Ren Project” Foundation of Yunnan Province of China;the “Lian Da Scholar Project” of Yunnan Normal University。

摘　　要：Hydrogen sulfide(H_(2) S) is a signaling molecule that plays important roles in biological systems.The exploration of H_(2) S as a new drug release trigger and its related fluorescent theranostic system is crucial for cancer bio-imaging and therapy.Herein,we designed a new two-photon ratiometric fluorescent theranostic prodrug(compound 1) and studied its spectroscopic properties and application in in vivo imaging.Compound 1 specifically reacted with H_(2) S and released the free active therapeutic component of 7-ethyl-10-hydroxycamptothecin,which was accompanied with a red-shift fluorescence emission signal from 460 nm to 545 nm.The exogenous and endogenous H_(2) S in living cells were imaged by compound 1 under one-photon and two-photon excitation.Furthermore,compound 1 monitored the H_(2) S concentration changes in Caenorhabditis elegans by fluorescence imaging.Additionally,it showed effective drug release activation in situ tumor with exogenous and endogenous H_(2) S as the trigger.The H_(2) S-sensitive activation and drug-release properties highlight the potential of theranostic compound 1 in future cancer treatment and therapy.

关 键 词：Hydrogen sulfide TWO-PHOTON Ratiometric fluorescent Theranostic prodrug BIO-IMAGING 

分 类 号：R914[医药卫生—药物化学] O657.3[医药卫生—药学]