Mild hyperthermia-enhanced chemo-photothermal synergistic therapy using doxorubicin-loaded gold nanovesicles  

作　　者：Zhuoting Deng Chao Jiang Muhammad Rizwan Younis Shan Lei Yaling He Haoxing Zheng Peng Huang Jing Lin 

机构地区：[1]Marshall Laboratory of Biomedical Engineering,International Cancer Center,Laboratory of Evolutionary Theranostics(LET),School of Biomedical Engineering,Shenzhen University Health Science Center,Shenzhen 518060,China

出　　处：《Chinese Chemical Letters》2021年第8期2411-2414,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (Nos.31771036,51703132);the Basic Research Program of Shenzhen (Nos.JCYJ20180507182413022,JCYJ20170412111100742);the Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project (No.2018B030308003)。

摘　　要：Gold nanovesicles(GVs) with unique plasmonic property and large cavity hold great potential as a stimuli-responsive nanocarrier to deliver drugs for efficient tumor chemotherapy and other therapies synergistically.Herein,we developed doxorubicin-loaded gold nanovesicles(DGVs),offering infrared thermal(IRT) and photoacoustic(PA) dual-modal imaging guided mild hype rthermia-enhanced chemophotothermal cancer synergistic therapy.The DGVs are self-assembled by gold nanoparticles modified with amphiphilic copolymer in a predetermined concentration of doxorubicin through film rehydration method.Under the influence of laser excitation,the as-prepared DGVs exhibited good photothermal effect,which triggered the structural disruption of GVs and thus,allowed the efficient release of encapsulated DOX to enhance cell uptake for fluorescence imaging and tumor chemotherapy,respectively.In addition,DGVs also showed a strong PA and IRT signals in vivo.Our study demonstrated the potential of DGVs as stimuli-responsive drug delivery systems and cancer theranostics.

关 键 词：Mild hyperthermia Chemo-photothermal synergistic therapy Gold nanovesicles DOXORUBICIN Photoacoustic imaging 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R943[医药卫生—药剂学] TQ460.4[医药卫生—药学]