结直肠腺瘤发病影响因素的研究进展  

Research progress on influencing factors for the pathogenesis of colorectal adenoma

作　　者：乌日嘎 宋晓彪[1] 梁永贵[1] 董帆 牛翻燕 李鹏达 梁志 董振宇 王继军[1] WU Riga;SONG Xiaobiao;LIANG Yonggui;DONG Fan;NIU Fanyan;LI Pengda;LIANG Zhi;DONG Zhenyu;WANG Jijun(The Third Department of General surgery,Baotou Central Hospital,Baotou,Inner Mongolia 014040,China;Central Clinical College of Baotou Medical College,Baotou,Inner Mongolia 014040,China)

机构地区：[1]内蒙古包头市中心医院普外三科,内蒙古包头014040 [2]内蒙古科技大学包头医学院中心临床学院,内蒙古包头014040

出　　处：《中国普通外科杂志》2021年第10期1235-1244,共10页China Journal of General Surgery

摘　　要：结直肠癌是全球第三大最常见的恶性肿瘤和第四大癌症相关死亡原因,严重威胁着人类健康。结直肠癌的发生发展是一个多步骤多因素的过程,通过多种信号通路,涉及众多肿瘤调控因子的激活、突变、失活和缺失等。研究表明,大约80%的结直肠癌是由结直肠腺瘤演变而来,该过程平均需要10年左右。因此,从结直肠腺瘤发生发展影响因素入手,减少或避免危险性因素同时发挥保护性因素的作用,从而影响结直肠腺瘤的发生,将能最终降低结直肠癌的发生。笔者结合国内外最新研究,从多个方面阐述结直肠腺瘤发生的危险因素及保护性因素。Colorectal cancer is the third most common malignant tumor and the fourth major cause of cancerrelated death in the world,which poses a serious threat to human health.The occurrence and development of colorectal cancer is a multi-step and multi-factor process,which involves the activation,mutation,inactivation and deletion of many tumor regulatory factors through a variety of signal pathways.Studies have shown that about 80%of colorectal cancer evolves from colorectal adenomas,and this process takes an average of about 10 years.Therefore,studying the factors affecting the occurrence and development of colorectal adenoma can reduce or avoid the risk factors,and meanwhile allow full play to the advantages of the protective factors,and then affect the occurrence of colorectal adenoma and ultimately reduce the occurrence of colorectal cancer.Based on the research progress at home and abroad,the authors address the risk factors and protective factors for the pathogenesis of colorectal adenoma from many aspects.

关 键 词：结直肠肿瘤 腺瘤 前驱病变 危险因素 综述 

分 类 号：R735.3[医药卫生—肿瘤]