Biology and pathology of the uterine micro environ merit and its natural killer cells  

作　　者：Fuyan Wang Anita Ellen Qualls Laia Marques-Fernandez Francesco Colucci 

机构地区：[1]Department of Obstetrics&Gynaecology,University of Cambridge,National Institute for Health Research Cambridge Biomedical Research Centre,Cambridge CB20SW,UK [2]Department of Biochemistry and Molecular Biology,and Zhejiang Key Laboratory of Pathophysiology,School of Medicine,Ningbo University,Ningbo 315211,China [3]Centre for Trophoblast Research,University of Cambridge,Cambridge CB23EG,UK

出　　处：《Cellular & Molecular Immunology》2021年第9期2101-2113,共13页中国免疫学杂志（英文版）

基　　金：Our lab is funded by the Wellcome Trust award 200841/Z/16/Z;FW was supported by grants from the National Natural Science Foundation of China 81501421.

摘　　要：Tissues are the new frontier of discoveries in immunology.Cells of the immune system are an integral part of tissue physiology and immunity.Determining how immune cells inhabit,housekeep,and defend gut,lung,brain,liver,uterus,and other organs helps revealing the intimate details of tissue physiology and may offer new therapeutic targets to treat pathologies.The uterine microenvironment modulates the development and function of innate lymphoid cells[ILC,largely represented by natural killer(NK)cells],macrophages,T cells,and dendritic cells.These immune cells,in turn,contribute to tissue homeostasis.Regulated by ovarian hormones,the human uterine mucosa(endometrium)undergoes ~400 monthly cycles of breakdown and regeneration from menarche to menopause,with its fibroblasts,glands,blood vessels,and immune cells remodeling the tissue into the transient decidua.Even more transformative changes occur upon blastocyst implantation.Before the placenta is formed,the endometrial glands feed the embryo by histiotrophic nutrition while the uterine spiral arteries are stripped of their endothelial layer and smooth muscle actin.This arterial remodeling is carried out by invading fetal trophoblast and maternal immune cells,chiefly uterine NK(uNK)cells,which also assist fetal growth.The tran sformed arteries no Ion ger resp ond to mater nal stimuli and meet the increasi ng dema nds of the growing fetus.This review focuses on how the everchanging uterine microenvironment affects uNK cells and how uNK cells regulate homeostasis of the decidua,placenta development,and fetal growth.Determining these pathways will help understand the causes of major pregnancy complications.

关 键 词：Natural killer cells Uterine microenvironment Pregnancy DECIDUA uNK 

分 类 号：R339.22[医药卫生—人体生理学]