虹膜膨隆与前后房眼压差关系的有限元分析  

Finite element analysis of the iris deformation under the intraocular pressure difference between the anterior and posterior chambers

作　　者：曹月红[1] 陈雁翎 蔡建程[2] Brazhenko Volodymyr Mochalin Ievgen CAO Yuehong;CHEN Yanling;CAI Jiancheng;BRAZHENKO Volodymyr;MOCHALIN Ievgen(Department of Ophthalmology,Zhejiang Province Jinhua People’s Hospital,Jinhua 321000,China;College of Engineering,Zhejiang Normal University,Jinhua 322117,China)

机构地区：[1]浙江省金华市人民医院眼科,金华321000 [2]浙江师范大学工学院,金华321000

出　　处：《中国眼耳鼻喉科杂志》2021年第6期435-438,444,共5页Chinese Journal of Ophthalmology and Otorhinolaryngology

基　　金：国家自然科学基金(51976201);金华市科学技术局重点项目(2019-3-016)。

摘　　要：目的本文采用数值仿真建模技术定量研究瞳孔阻滞时虹膜在前后房眼压差作用下的变形程度。方法根据虹膜组织的力学特性,建立虹膜变形的有限元分析模型,施加不同前后房眼压差数值计算虹膜变形,分析虹膜面应变、曲率半径以及前房角角度与前后房眼压差之间的关系。结果当前后房眼压差超过50 Pa,虹膜有明显的膨隆;达到150 Pa时,虹膜最大变形量已接近2 mm,且虹膜几乎贴近角膜,严重阻碍房水从前房角排出,容易引发闭角型青光眼。虹膜曲率半径初起随前后房眼压差增加急速减小,高于50Pa后曲率半径减小速度明显降低。虹膜最大变形和面应变与前后房眼压差之间基本呈线性关系。结论研究结果有助于从生物力学角度了解虹膜在前后房眼压差作用下的力学特性,为闭角型青光眼的发病机制、诊断和治疗提供指导。Objective Numerical simulation technology was used to quantitatively study the degree of iris deformation under the intraocular pressure difference between the anterior and posterior chambers during pupillary block in this paper.Methods According to the mechanical properties of iris tissue,the finite element analysis model of iris deformation was established,and different intraocular pressure difference was applied to calculate the iris deformation.The relationship between iris surface strain,iris curvature,angle and the intraocular pressure difference was analyzed.Results When the intraocular pressure difference exceeded 50 Pa,the iris had noticeable bombé,and when the intraocular pressure difference reached 150 Pa,the maximum deformation of the iris was close to 2 mm with its position very close to the cornea,which seriously hindered the aqueous humor exiting from the anterior chamber angle,causing angle closure glaucoma.The radius of curvature of iris decreased rapidly with the increase of the intraocular pressure difference at the beginning,and then decreased rather slowly after the intraocular pressure difference reached 50 Pa.The maximum deformation and the strain of iris had the linear relationship with the intraocular pressure difference.Conclusions The results are helpful to understand the mechanical properties of human iris under the action of anterior and posterior chamber pressure difference from the perspective of biomechanics,and provide guidance for the pathogenesis,diagnosis and treatment of angle closure glaucoma.

关 键 词：虹膜变形 前后房眼压差 青光眼 有限元分析 数值研究 

分 类 号：R779.6[医药卫生—眼科]