乳腺癌组织中Bmi-1和CARD9表达及其与淋巴结转移和预后的关联  

The expression of Bmi-1 and CARD9 in breast cancer tissues and their correlation with lymph node metastasis and prognosis

作　　者：张瑞瑞[1] 赵桓玉 周武碧[1] 孙艳兰[1] 刘海燕[1] ZHANG Ruirui;ZHAO Huanyu;ZHOU Wubi;SUN Yanlan;LIU Haiyan(Department of Pathology, Huaian First Hospital Affiliated to Nanjing Medical University, Nanjing 223300, China)

机构地区：[1]南京医科大学附属淮安第一医院病理科,江苏南京223300

出　　处：《西部医学》2021年第11期1642-1646,1659,共6页Medical Journal of West China

基　　金：“十三五”南京市卫生青年人才培养工程第三层次(QRX17173)。

摘　　要：目的探究乳腺癌组织中Bmi-1、胱天蛋白酶募集域蛋白9(CARD9)表达及其与淋巴结转移、预后的关联性。方法以我院2017年1月~2018年11月96例乳腺癌患者为研究对象,检测其乳腺癌组织及癌旁组织中Bmi-1、CARD9表达情况;分析乳腺癌组织中Bmi-1、CARD9表达情况与临床病理及预后的关系。结果乳腺癌组织中Bmi-1、CARD9阳性表达率均高于癌旁组织(P<0.05);Bmi-1阳性表达组在TNM分期为Ⅲ、Ⅳ期、组织学分级为Ⅲ级、肿瘤长径≥2 cm、存在淋巴结转移、ER+方面的人数比例高于Bmi-1阴性表达组,CARD9阳性表达组在TNM分期为Ⅲ、Ⅳ期、肿瘤长径≥2 cm、存在淋巴结转移方面的人数比例高于CARD9阴性表达(P<0.05);TNM分期为Ⅲ、Ⅳ期、肿瘤长径≥2 cm、存在淋巴结转移是影响Bmi-1表达的危险因素,TNM分期为Ⅲ、Ⅳ期、存在淋巴结转移是影响CARD9表达的危险因素(P<0.05);Bmi-1、CARD9不同表达情况的1年生存率对比无明显差异(P>0.05);乳腺癌组织中Bmi-1、CARD9表达情况预测患者术后1年生存情况的AUC分别为0.561、0.628。结论乳腺癌组织中Bmi-1、CARD9阳性表达率较高,且其阳性表达与淋巴结转移、TNM分期相关,但Bmi-1、CARD9表达情况与术后1年生存情况无明显关联。Objective To explore the expression of Bmi-1 and caspase recruitment domain-containing protein 9(CARD9)in breast cancer tissues and their correlation with lymph node metastasis and prognosis.Methods A total of 96 breast cancer patients between January 2017 and November 2018 were enrolled as the research objects.The expression of Bmi-1 and CARD9 in breast cancer tissues and para-carcinoma tissues was detected.And their relationship with clinical pathology and prognosis was analyzed.Results The positive expression rates of Bmi-1 and CARD9 in breast cancer tissues were higher than those in para-carcinoma tissues(P<0.05).The proportions of patients with TNM staging at stageⅢandⅣ,histological grading at gradeⅢ,long diameter of tumor not shorter than 2 cm,lymph node metastasis and ER+in Bmi-1 positive-expression group were higher than those in Bmi-1 negative-expression group.The proportions of patients with TNM staging at stageⅢandⅣ,long diameter of tumor not shorter than 2 cm and lymph node metastasis in CARD9 positive-expression group were higher than those in CARD9 negative-expression group(P<0.05).TNM staging at stageⅢandⅣ,long diameter of tumor not shorter than 2 cm and lymph node metastasis were risk factors of Bmi-1 expression,while TNM staging at stageⅢandⅣand lymph node metastasis were risk factors of CARD9 expression(P<0.05).There was no significant difference in 1-year survival rate among patients with different Bmi-1 and CARD9(P>0.05).AUC values of Bmi-1 and CARD9 in breast cancer tissues for predicting 1-year survival were 0.561 and 0.628,respectively.Conclusion The positive expression rates of Bmi-1 and CARD9 in breast cancer tissues are relatively high,and their positive expression is related to lymph node metastasis and TNM staging,while the expression of Bmi-1 and CARD9 is not significantly related to the survival at 1 year after surgery.

关 键 词：乳腺癌 BMI-1 胱天蛋白酶募集域蛋白9 淋巴结转移 预后 

分 类 号：R737.9[医药卫生—肿瘤]