STING信号通路在肿瘤中的研究进展  

Research progress of STING signaling pathway in tumor

作　　者：陈仕豪 王雪[1] 周雪冰 张鑫 任香善[1] CHEN Shi-Hao;WANG Xue;ZHOU Xue-Bing;ZHANG Xin;REN Xiang-Shan(Department of Pathology,Tumor Research Center,School of Medicine,Yanbian University,Yanji 133002,China)

机构地区：[1]延边大学医学院病理学教研室肿瘤研究中心,延吉133002

出　　处：《中国免疫学杂志》2021年第19期2423-2427,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(31460303,81660609);吉林省科技厅项目(20180101007);吉林省教育厅项目(JJKH20191116KJ)资助。

摘　　要：干扰素基因刺激因子(STING)是新发现的外源和内源性DNA的细胞内感知器,已被公认为TBK1/IRF3和NF-κB信号通路免疫应答的激动剂,在宿主防御、自身免疫性疾病及肿瘤免疫等方面发挥重要作用。本综述着重于STING通路在肿瘤发生、发展及应用中的作用,为今后抗肿瘤的临床策略提供新的方向。Stimulator of interferon genes(STING)is a newly discovered intracellular perceptor of exogenous and endogenous DNA,and has been recognized as agonists of immune responses to TBK1/IRF3 and NF-κB signaling pathways.It plays a key role in host defense,autoimmune diseases,and tumor immunity.This review focuses on role of the STING pathway in tumorigenesis,develop-ment and application,and provides new directions for future anti-tumor clinical strategies.

关 键 词：肿瘤 STING信号通路 免疫应答 免疫治疗 

分 类 号：R730.2[医药卫生—肿瘤]