Efficacy and effect on related brain-gut peptides of acupoint sticking therapy for functional dyspepsia  

穴位贴敷治疗功能性消化不良的疗效及对相关脑肠肽的影响

作　　者：Kong Wei-guang He Tian-feng Kong Xie-he 孔伟光;何天峰;孔谐和(译)(Department of Spleen and Stomach Diseases,Inner Mongolia Hospital of Traditional Chinese Medicine,Huhhot 010020,China;Department of Acupuncture,Jiading Hospital of Traditional Chinese Medicine,Shanghai,Shanghai 201899,China;不详)

机构地区：[1]Department of Spleen and Stomach Diseases,Inner Mongolia Hospital of Traditional Chinese Medicine,Huhhot 010020,China [2]Department of Acupuncture,Jiading Hospital of Traditional Chinese Medicine,Shanghai,Shanghai 201899,China [3]不详

出　　处：《Journal of Acupuncture and Tuina Science》2021年第5期384-388,共5页针灸推拿医学（英文版）

基　　金：内蒙古自治区卫生和计划生育委员会科研项目,No.201703065.

摘　　要：Objective:To observe the efficacy of acupoint sticking with Jianpi Tongjing Zhitong ointmerrt in the treatment of functional dyspepsia due to liver-qi stagnation and spleen deficiency and its effect on serum 5-hydroxytryptamine(5-HT)and ghrelin con tents.Methods:One hun dred patients with functi onal dyspepsia due to liver-qi stag nation and spleen deficiency were divided into a treatment group and a control group by the random number table method,with 50 cases in each group.The treatment group received acupoint sticking with Jianpi Tongjing Zhitong ointment and the control group was treated with mosapride citrate orally.Patients were treated for 4 weeks as a course.The therapeutic efficacy was compared after one-course treatment and the differences in gastric emptying rate,and serum 5-HT and ghrelin contents between groups were compared before and after treatment.Results:The total effective rate was 79.6%in the control group and 89.4%in the treatment group,showing significantly differe nt between groups(P<0.05).After treatme nt,the gastric empt ying rate and serum ghreli n con tent of the two groups in creased significantly,and the serum 5-HT content decreased significantly,the intra-group differe nces were significant(all P<0.01).After treatment,the gastric emptying rate and serum ghrelin content were significantly higher in the treatment group than those in the control group,while the serum 5-HT was significant lower in the treatment group,the inter-group differences were significant(all P<0.05).A negative correlation(r=-0.59)was observed between serum 5-HT content and gastric emptying rate,and a positive correlation(r=0.64)was observed between serum ghrelin content and gastric emptying rate,showing statistical significance(all P<0.01).Conclusion:Acupoint sticking with Jianpi Tongjing Zhitong ointment has a remarkable ciinical efficacy in treating patie nts with functional dyspepsia due to liver-qi stagnation and spleen deficiency and is able to in fluence the secretion of serum 5-HT and ghrelin-1 mproving the目的:观察健脾通经止痛膏穴位贴敷治疗肝郁脾虚型功能性消化不良的临床疗效及对血清中5-羟色胺(5-HT)和胃促生长素(Ghrelin)含量的影响.方法:将100例肝郁脾虚型功能性消化不良患者按随机数字表法分为治疗组和对照组,每组50例.治疗组予健脾通经止痛膏穴位贴敷治疗,对照组予枸橼酸莫沙必利片口服治疗.4周为1个疗程,1个疗程后比较两组的临床疗效及治疗前后患者胃排空率、血清5-HT和Ghrelin的含量.结果:对照组总有效率为79.6%,治疗组为89.4%,两组比较差异有统计学意义(P<0.05).两组治疗后胃排空率和血清Ghrelin含量显著升高,血清5-HT含量明显降低,组内差异均有统计学意义(均P<0.01).治疗组胃排空率和血清Ghrelin含量明显高于对照组,血清5-HT含量明显低于对照组,组间差异均有统计学意义(均P<0.05).血清5-HT水平与胃排空率呈负相关(r=-0.59),血清Ghrelin水平与胃排空率呈正相关(r=0.64),具有统计学意义(均P<0.01).结论:健脾通经止痛膏穴位贴敷治疗肝郁脾虚型功能性消化不良临床疗效显著,并能影响患者血清5-HT和Ghrelin的分泌;通过调节脑肠肽的分泌,从而影响胃肠道运动,可能是其治疗功能性消化不良的潜在作用机制.

关 键 词：Acupoi nt Sticking Therapy Emplastrum Therapy DYSPEPSIA Liver-qi Stag nation日nd Spleen Deficie ncy Brain-gut Peptide 5-HYDROXYTRYPTAMINE Ghrelin 

分 类 号：R245.9[医药卫生—针灸推拿学]