基于SEER数据库的原发性肝血管肉瘤预后因素分析  

Analysis of prognostic factors of primary hepatic angiosarcoma based on SEER database

作　　者：毛金茜 李毅清[1] 胡进 润晓勤[1] MAO Jinqian;LI Yiqing;HU Jin(Department of Vascular Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;不详)

机构地区：[1]华中科技大学同济医学院附属协和医院血管外科,武汉430022 [2]华中科技大学同济医学院附属协和医院乳腺甲状腺外科,武汉430022

出　　处：《临床外科杂志》2021年第10期980-984,共5页Journal of Clinical Surgery

基　　金：国家自然科学基金资助项目(81571349)。

摘　　要：目的分析原发性肝血管肉瘤的预后影响因素。方法从SEER数据库中筛选出290例1975~2016年间诊断为原发性肝血管肉瘤的病人资料,对其临床基线特征进行生存分析。结果年龄≥70岁、肿瘤直径>85 mm、男性、远处转移、未行原发部位手术和未化疗是影响预后的独立危险因素(P<0.05)。远处转移行原发部位手术组、无转移未行原发部位手术组、局部转移未行原发部位手术组和远处转移未行原发部位手术组病人是否化疗均具有生存差异(P<0.05)。结论原发性肝血管肉瘤罕见且预后差,主要发生于老年男性,早期发现和诊断可提高生存率。原发部位手术和化疗可以改善预后,但无远处转移行原发部位手术治疗的病人继续行化疗的获益可能不明显。To investigate the prognostic factors of primary hepatic angiosarcoma(PHA).Methods We extracted 290 PHA cases between 1975 and 2016 from the Surveillance,Epidemiology and End Results database and performed survival analyses on the baseline characteristics.Results Age≥70 years old,tumor size>85 mm,male,distant metastasis,no primary site surgery(PSS)and no chemotherapy were independent risk factors of PHA patients'prognosis(P<0.05).There was a survival difference between chemotherapy and no chemotherapy in patients who were distant metastasis with PSS,no metastasis without PSS,local metastasis without PSS and distant metastasis without PSS,respectively(P<0.05).Conclusion PHA was rare with a poor prognosis and mainly occurred in elderly males.Early detection and diagnosis could improve survival rate.PSS and chemotherapy could improve prognosis,but patients who underwent PSS without distant metastasis might not benefit from chemotherapy.

关 键 词：肝血管肉瘤 治疗 预后 SEER数据库 

分 类 号：R735.7[医药卫生—肿瘤]