舍曲林合并脑电生物反馈、认知行为疗法治疗首发青少年焦虑障碍的对照研究  

Controlled Study of Sertraline Combined with Electroencephalogram Biofeedback and Cognitive Behavioral Therapy in the Treatment of First-Episode Adolescent Anxiety Disorder

作　　者：王源莉[1] 李淑英[1] 杨灿 张瑶 吕培培[1] 阳秋荣 WANG Yuanli;LI Shuying;YANG Can;ZHANG Yao;LU Peipei;YANG Qiurong(Department of Psychiatry,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院精神医学科,河南郑州450052

出　　处：《河南医学研究》2021年第32期5979-5982,共4页Henan Medical Research

基　　金：河南省医学科技攻关计划项目(201602071)。

摘　　要：目的探讨舍曲林联合脑电生物反馈、认知行为疗法治疗首发青少年焦虑障碍患者的疗效。方法选取2019年12月至2020年12月于郑州大学第一附属医院精神医学科住院治疗的首发青少年焦虑障碍患者,采用随机数字表法将76例患者随机分为两组:研究组接受舍曲林联合脑电生物反馈、认知行为疗法,对照组单一口服舍曲林,疗程共6周。以汉密尔顿焦虑量表(HAMA)、症状自评量表(SCL-90)于治疗前和治疗2、4、6周末分别评定疗效。比较两组不良反应发生情况。结果两组治疗后HAMA、SCL-90评分均较治疗前下降,治疗组于4周末HAMA、SCL-90评分均较对照组降低。两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论舍曲林合并脑电生物反馈、认知行为疗法治疗首发青少年焦虑障碍疗效优于单用舍曲林。Objective To investigate the efficacy of sertraline combined with electroencephalogram biofeedback and cognitive behavioral therapy in the treatment of first-episode adolescent patients with anxiety disorder.Methods First-episode adolescent anxiety disorder patients hospitalized in the department of psychiatry of the First Affiliated Hospital of Zhengzhou University from December 2019 to December 2020 were selected.Seventy-six adolescent patients with anxiety disorder were divided into two groups by random number table method.Sertraline combined with electroencephalogram biofeedback and cognitive behavioral therapy in the study group,and Sertraline alone in the control group,for a course of 6 weeks.Hamilton anxiety scale(HAMA) and symptom self-rating scale(SCL-90) were used to evaluate efficacy before treatment and at the end of 2,4 and 6 weeks of treatment.The incidence of adverse reactions was compared between the two groups.Results After treatment,the scores of HAMA and SCL-90 in both groups decreased compared with before treatment,and the scores of HAMA and SCL-90 in the treatment group were lower than those in the control group at the end of 4 weeks.There was no significant difference in total incidence of adverse reactions between 2 groups(P>0.05).Conclusion Sertraline combined with electroencephalogram biofeedback and cognitive behavioral therapy is more effective than sertraline alone in the treatment of first-episode adolescent anxiety disorder.

关 键 词：舍曲林 脑电生物反馈 认知行为治疗 青少年焦虑障碍 

分 类 号：R749[医药卫生—神经病学与精神病学]