调强放疗与三维适形放疗对晚期非小细胞肺癌患者的疗效比较  

Comparison of effects of intensity-modulated radiotherapy and three-dimensional conformal radiotherapy on patients with advanced non-small cell lung cancer

作　　者：刘维鹏 冯连杰[1] 孟宪宇[1] 赵世杰[1] 付小娜 LIU Weipeng;FENG Lianjie;MENG Xianyu;ZHAO Shijie;FU Xiaona(The Third Department of Radiotherapy of Anyang Cancer Hospital,Anyang 455000 Henan,China)

机构地区：[1]安阳市肿瘤医院放疗三科,河南安阳455000

出　　处：《中国民康医学》2021年第20期136-138,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较调强放疗与三维适形放疗对晚期非小细胞肺癌(NSCLC)患者的疗效。方法:选取80例晚期NSCLC患者为研究对象,按随机数字表法分为对照组和研究组各40例。对照组采用三维适形放疗,观察组采用调强放疗,比较两组临床疗效、1年生存率和不良反应发生率。结果:研究组客观缓解率为65.00%,对照组客观缓解率为57.50%,组间比较差异无统计学意义(P>0.05);研究组1年生存率为90.00%,对照组1年生存率为85.00%,组间比较差异无统计学意义(P>0.05);两组消化道反应和白细胞减少发生率比较,差异均无统计学意义(P>0.05);研究组放射性肺炎、放射性脊髓损伤和放射性肝损伤发生率均低于对照组,差异有统计学意义(P<0.05)。结论:调强放疗与三维适形放疗对晚期NSCLC患者的疗效相当,但调强放疗引起的放射性肺炎、放射性脊髓损伤和放射性肝损伤发生率均低于三维适形放疗。Objective:To compare effects of intensity-modulated radiotherapy and three-dimensional conformal radiotherapy on patients with advanced non-small cell lung cancer(NSCLC).Methods:80 patients with advanced NSCLC were selected as the research objects,and were divided into control group and t study group according to the random number table method,40 cases in each group.Three-dimensional conformal radiotherapy was used in the control group,while intensity-modulated radiotherapy was given to the observation group.The objective response rate,1-year survival rate and incidence of adverse reactions were compared between the two groups.Results:The objective remission rate of the study group was 65.00%,that of the control group was 57.50%,and the difference was not statistically significant(P>0.05).The 1-year survival rate of the study group was 90.00%,that of the control group was 85.00%,and the difference was not statistically significant(P>0.05).There were no significant differences in the incidence of gastrointestinal reactions and leukopenia between the two groups(P>0.05).Further,the incidence of radiation-induced pneumonia,radiation-induced spinal cord injury and radiation-induced liver injury in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Intensity-modulated radiotherapy and three-dimensional conformal radiotherapy have the same effects on the patients with advanced NSCLC.However,the incidence of radiation-induced pneumonia,radiation-induced spinal cord injury and radiation-induced liver injury of intensity-modulated radiotherapy are lower than those of three-dimensional conformal radiotherapy.

关 键 词：调强放疗 三维适形放疗 晚期 非小细胞肺癌 客观缓解率 1年生存率 不良反应 

分 类 号：R730.55[医药卫生—肿瘤]