神经肽Y在人脑局灶性皮层发育不良不同Palmini病理亚型间的表达差异  

Neuropeptide Y expression differences of Palmini pathological subtypes in human brain focal cortical dysplasia

作　　者：刘辉[1] 刘吉祥[1] 詹绍萍 李文玲[3] 武江[4] 刘永军[1] 张鹏[1] 申仑[1] 李建华[1] Hui Liu;Jixiang Liu;Shaoping Zhan;Wenling Li;Jiang Wu;Yongjun Liu;Peng Zhang;Lun Shen;Jianhua Li(Department of Neurosurgery,The First Hospital of Handan,Handan 056002,China;Department of Special Diagnosis,The 980 Hospital of PLA,Handan 056001,China;Department of Neurosurgery,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Department of Neurosurgery,Hebei Provincial People’s Hospital,Shijiazhuang 050000,China)

机构地区：[1]邯郸市第一医院神经外科,河北邯郸056002 [2]解放军九八〇医院邯郸院区特诊科,河北邯郸056001 [3]河北医科大学附属第二医院神经外科,石家庄050000 [4]河北省人民医院神经外科,石家庄050000

出　　处：《中华神经创伤外科电子杂志》2021年第5期293-296,共4页Chinese Journal Of Neurotraumatic Surgery：Electronic Edition

摘　　要：目的探讨不同Palmini病理亚型局灶性脑皮层发育不良(FCD)与正常人脑中神经肽Y(NPY)表达的差异,以及FCD诱发癫痫的机制。方法收集河北省人民医院神经外科自2007年5月至2011年10月收治的行癫痫手术后病理结果符合FCD的患者58例作为试验组。以Palmini分类标准,按病理亚型分为4组:ⅠA组9例、ⅠB组26例、ⅡA组10例、ⅡB组13例。同时取10例正常人脑组织设为对照组。观察FCD患者癫痫发病临床特点,FCD患者及正常人脑中NPY免疫反应阳性细胞数目差异。结果FCDⅡB组癫痫发作频率明显高于其他病理亚型组。FCDⅡB组NPY免疫反应阳性细胞数目与对照组比较明显增加,差异有统计学意义(P<0.05);FCD组中FCDⅠA、FCDⅠB、FCDⅡA各亚型与对照组比较,差异无统计学意义(P>0.05)。结论FCD各病理亚型中FCDⅡB型的NPY免疫反应阳性细胞反应明显,FCDⅡB致痫机制可能与NPY的表达增高有关。Objective To explore neuropeptide Y(NPY)expression differences in different pathological subtypes of human brain focal cortical dysplasia(FCD)and in normal human brain,and the mechanism by which FCD induced epilepsy.Methods Fifty-eight patients with FCD were collected from the Department of Neurosurgery of Hebei Provincial People’s Hospital from May 2007 to October 2011.According to Palmini classification criteria of different pathological subtypes,they were divided into 4 groups:9 cases in groupⅠA,26 cases in groupⅠB,10 cases in groupⅡA and 13 cases in groupⅡB.While 10 normal human brain tissues were taken as the control group.The clinical characteristics of epilepsy in patients with FCD and the differences in the number of positive NPY immunoreactive cells between patients with FCD and normal human brain were observed.Results The frequency of seizures in FCDⅡB group was significantly higher than in the other pathological subtypes.The number of NPY immunoreactive cells in FCDⅡB group was significantly increased compared with the control group,the difference was statistically significant(P<0.05);There was no significant difference in FCDⅠA,FCDⅠB and FCDⅡA subtypes between FCD group and control group(P>0.05).Conclusion The NPY immunoreactive cells of FCDⅡB were significantly positive in all pathological subtypes of FCD.FCDⅡB epileptogenic mechanism may be related to the increased expression of NPY.

关 键 词：局灶性皮层发育不良 神经肽Y 病理亚型 癫痫 

分 类 号：R741[医药卫生—神经病学与精神病学]