胰高血糖素样肽-1联合复方左旋多巴治疗帕金森病合并糖尿病的效果  

Effects of glucagon-like peptide-1 combined with Compound Levodopa on Parkinson disease with diabetes mellitus patients

作　　者：范磊[1] 刘星亮[1] 娄展 王颖 王月娟 FAN Lei;LIU Xingliang;LOU Zhan;WANG Ying;WANG Yuejuan(The third Department of Neurology,the First Affiliated Hospital of Hebei North University,Hebei Province,Zhangjiakou075000,China)

机构地区：[1]河北北方学院附属第一医院神经内三科,河北张家口075000

出　　处：《中国医药导报》2021年第29期82-85,共4页China Medical Herald

基　　金：河北省卫生健康委科研基金项目(20190899)。

摘　　要：目的观察胰高血糖素样肽-1(GLP-1)联合复方左旋多巴治疗帕金森病(PD)合并糖尿病(DM)的效果。方法选取2018年1月至2020年6月河北北方学院附属第一医院接诊的符合PD合并DM的患者158例作为研究对象,按照随机数字表法将其分为对照组(79例)和研究组(79例)。对照组给予皮下注射胰岛素与口服复方左旋多巴片的治疗方式,研究组给予皮下注射GLP-1与口服复方左旋多巴片的治疗方式,两组均治疗6个月。比较两组治疗前后蒙特利尔认知评估量表(Mo CA),帕金森病评定量表(UPDRS)中的UPDRSⅡ(日常生活活动能力)、UPDRSⅢ(运动能力)评分变化。结果治疗过程中研究组有2例患者中途退出,本研究最终纳入156例患者。治疗后,两组Mo CA评分高于治疗前,UPDRSⅡ、Ⅲ评分均低于治疗前,且研究组MoCA评分高于对照组,UPDRSⅡ、Ⅲ评分低于对照组,差异有统计学意义(P <0.05)。结论 GLP-1联合复方左旋多巴不仅有助于改善PD合并DM患者的认知功能,而且有助于提高此类患者的生活质量和运动能力。Objective To study the effect of glucagon-like peptide-1(GLP-1) combined with Compound Levodopa on Parkinson disease(PD) with diabetes mellitus(DM) patients.Methods A total of 158 PD with DM patients admitted to the First Affiliated Hospital of Hebei North University from January 2018 to June 2020 were selected as the research objects.They were divided into control group(79 cases) and research group(79 cases) according to the random number table method.The control group was given subcutaneous injection of insulin and oral Compound Levodopa Tablets,and the research group was given subcutaneous injection of GLP-1 and oral Compound Levodopa Tablets.The treatment time for both groups was six months.Before and after treatment,the changes of Montreal cognitive assessment scale(MoCA),unified Parkinson disease rating scale(UPDRS) Ⅱ(activity of daily living) and UPDRS Ⅲ(exercise ability)scores in UPDRS were compared.Results During the treatment,two patients in the research group dropped out,and156 patients were eventually enrolled in the study.After treatment,MoCA score was higher than before treatment,UPDRS Ⅱ and Ⅲ scores were lower than before treatment,and the MoCA score of the research group was higher than that of the control group,and the UPDRS Ⅱ and Ⅲ scores were lower than that of the control group,with statistical significance(P < 0.05).Conclusion GLP-1 combined with Compound Levodopa can not only improve the cognitive function of PD with DM patients,but also improve the quality of life and exercise ability of these patients.

关 键 词：胰高血糖素样肽-1 复方左旋多巴 帕金森病 糖尿病 疗效 

分 类 号：R742[医药卫生—神经病学与精神病学]