长链非编码RNA-PVT1表达与消化系统恶性肿瘤预后及临床病理关系的meta分析  

Meta-analysis of the association between long Non-coding RNA-PVT1 expression and the prognosis and clinicopathology of digestive system malignant tumors

作　　者：刘莹涛 方昌中 陈文亮[2] LIU Yingtao;FANG Changzhong;CHEN Wenliang(Graduate School,Shanxi Medical University,Shanxi Province,Taiyuan030001,China;Department of General Surgery,Second Hospital of Shanxi Medical University,Shanxi Province,Taiyuan030001,China)

机构地区：[1]山西医科大学研究生院,山西太原030001 [2]山西医科大学第二医院普外科,山西太原030001

出　　处：《中国医药导报》2021年第29期106-111,共6页China Medical Herald

基　　金：山西省自然科学基金面上项目(201801D121320)。

摘　　要：目的研究长链非编码RNA(lncRNA)-浆细胞瘤变异易位1(PVT1)表达与消化系统恶性肿瘤患者的临床病理特征和预后的关系。方法检索Web of Science、EMBASE和PubMed数据库,检索时间截至2021年1月。根据检索策略及纳入、排除标准对文章进行筛选,并提取相关数据。使用RevMan v5.3进行meta分析。结果本研究共纳入了32项研究,2873例患者。meta分析结果示:高表达PVT1与较差的总生存期(HR=1.71,95%CI:1.54~1.89,P <0.000 01)和无病生存期(HR=1.95,95%CI:1.67~2.29,P <0.000 01)有关。PVT1高表达与肿瘤直径(OR=2.02,95%CI:1.43~2.86,P <0.0001)、TNM分期(OR=3.42,95%CI:2.86~4.08,P <0.000 01)、淋巴结转移(OR=3.04,95%CI:2.41~3.84,P <0.000 01)、肿瘤分化(OR=1.81,95%CI:1.21~2.72,P=0.004,P <0.001)、远处转移(OR=2.91,95%CI:2.06~4.11,P <0.000 01)和浸润深度(OR=5.19,95%CI:3.52~7.66,P <0.000 01)呈正相关。结论 PVT1可以用来评估消化系统恶性肿瘤患者的临床病理特征和预后。Objective To study the relationship between long non coding RNA-plasmacytoma variant translocation 1(PVT1) and the clinicopathological features and prognosis of digestive system malignancies.Methods The Web of Science,EMBASE,and PubMed were searched,the search ended on January 2021.According to the retrieval strategy and inclusion and exclusion criteria,the literatures were screened and the relevant data were extracted.RevMan v5.3 software was used for meta analysis.Results A total of 32 studies involving 2873 patients were included.The highly expressed PVT1 levels were potentially connected with poorer overall survival(HR = 1.71,95%CI:1.54-1.89,P < 0.000 01)and disease free survival(HR = 1.95,95%CI:1.67-2.29,P < 0.000 01).Highly expressed PVT1 levels were also positively correlated with diameter of tumor(OR = 2.02,95%CI:1.43-2.86,P < 0.000 01),TNM stage(OR = 3.42,95%CI:2.86-4.08,P < 0.000 01),lymph node metastasis(OR = 3.04,95%CI:2.41-3.84,P < 0.000 01),tumor differentiation(OR = 1.81,95%CI:1.21-2.72,P = 0.004),distant metastasis(OR = 2.91,95%CI:2.06-4.11,P < 0.000 01) and infiltration depth(OR = 5.19,95%CI:3.52-7.66,P < 0.000 01).Conclusion PVT1 can be used to gauge clinicopathological characteristics and outcomes in patients withdigestive system malignant tumors.

关 键 词：长链非编码RNA 浆细胞瘤变异易位1 消化系统恶性肿瘤 预后 临床病理特征 META分析 

分 类 号：R73[医药卫生—肿瘤]