CT-3D重建辅助肝动脉化疗栓塞治疗的临床疗效及对AFP-L3、DCP的影响  

Clinical Efficacy of CT-3D Reconstruction Assisted Hepatic Arterial Chemoembolization and its Influence on AFP-L3 and DCP

作　　者：姜海燕[1] 赵春红[1] JIANG Hai-yan;ZHAO Chun-hong(Department of Infection,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)

机构地区：[1]佳木斯市中心医院感染科,黑龙江佳木斯154002

出　　处：《医学信息》2021年第22期34-36,共3页Journal of Medical Information

基　　金：黑龙江省卫生健康委科研课题(编号:2019-341)。

摘　　要：目的探讨CT-3D重建辅助肝动脉化疗栓塞(TACE)治疗的临床疗效及对甲胎蛋白异质体(AFP-L3)和脱γ-羧基凝血酶原(DCP)的影响。方法选取2020年1月-2021年1月我院收治的62例原发性肝癌患者作为研究对象,采用随机数字表法分为观察组和对照组,各31例。对照组采用常规TACE治疗,观察组采用CT-3D重建辅助TACE治疗,比较两组临床治疗疗效、AFP-L3及DCP水平、术中治疗情况(栓塞面积、碘油用量以及手术时间)及复发情况。结果观察组ORR高于对照组,差异有统计学意义(P<0.05);两组治疗后AFP-L3、DCP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组栓塞面积、碘油用量以及手术时间均低于对照组,差异有统计学意义(P<0.05);随访3个月后,观察组复发率为6.45%,低于对照组的25.81%,差异有统计学意义(P<0.05)。结论CT-3D重建辅助TACA治疗能够有效提高临床疗效,改善AFP-L3以及DCP水平,同时有利于减少对患者造成的损伤,从而促进患者术后康复,避免疾病复发。Objective To analyze the clinical efficacy of CT-3D reconstruction assisted hepatic artery chemoembolization(TACE)therapy and its effect on alpha-fetoprotein alloplasm(AFP-L3)and decarboxylic prothrombin(DCP).Methods A total of 62 patients with primary liver cancer admitted to our hospital from January 2020 to January 2021 were selected as subjects.They were divided into observation group and control group by random number table method,with 31 cases in each group.The control group was treated with conventional TACE,and the observation group was treated with CT-3D reconstruction combined with TACE.The clinical efficacy,AFP-L3 and DCP levels,intraoperative treatment(embolization area,iodized oil dosage and operation time)and recurrence were compared between the two groups.Results The ORR rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The levels of AFP-L3 and DCP in the two groups after treatment were lower than those before treatment,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).The embolization area,iodized oil dosage and operation time in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 3 months of follow-up,the recurrence rate of the observation group was 6.45%,which was lower than 25.81%of the control group,and the difference was statistically significant(P<0.05).Conclusion CT-3D reconstruction assisted TACA treatment can effectively improve the clinical efficacy and improve the levels of AFP-L3 and DCP.At the same time,it is beneficial to reduce the damage caused to patients,so as to promote the recovery of patients after surgery,and avoid disease recurrence.

关 键 词：甲胎蛋白异质体 脱γ-羧基凝血酶原 CT-3D重建 肝动脉化栓塞 

分 类 号：R735.7[医药卫生—肿瘤]